Results 51 to 60 of about 92,433 (265)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Trajectory Pattern Recognition in a Multi‐Airport Systems Based on a New 3D Multi‐Feature Trajectory Compression

IET Intelligent Transport Systems
With the rapid development of the global aviation industry, multi‐airport systems have emerged as a critical component of large urban clusters and regional aviation networks.
Ligang Yuan, Wenlu Chen, Haiyan Chen, Bin Wang, Xinding Zhou   +4 more
doaj   +1 more source

An Intelligent Traffic Flow Control System Based on Radio Frequency Identification and Wireless Sensor Networks

International Journal of Distributed Sensor Networks, 2014
This study primarily focuses on the use of radio frequency identification (RFID) as a form of traffic flow detection, which transmits collected information related to traffic flow directly to a control system through an RS232 interface. At the same time,
Kuei-Hsiang Chao, Pi-Yun Chen
doaj   +1 more source

Traffic Flow Optimization on Roundabouts [PDF]

Procedia - Social and Behavioral Sciences, 2014
The aim of this article is to propose an optimization strategy for traffic flowon roundabouts using amacroscopic approach. The roundabout is modeled as a sequence of 2 × 2 junctions with one main lane and secondary incoming and outgoing roads. We consider two cost functionals: the total travel time and the total waiting time, which give an estimate of ...
Obsu, Legesse Lemecha, Delle Monache, Maria Laura, Goatin, Paola, Kassa, Semu Mitiku   +3 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Testing Traffic Flow Models [PDF]

, 2003
The huge number of different traffic flow models available calls for an attempt to classify, simplify and assess those models. In principle, this is simple to accomplish, since the principal algorithms for assigning quality measures such as X 2 are well known. However, due to a lack of publicly available data, a commonly agreed upon benchmark could not
Brockfeld, Elmar, Wagner, Peter
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Effect of Crosswalks on Traffic Flow

European Journal of Transport and Infrastructure Research, 2018
In urban areas and especially in inner cities, pedestrians crossing the road considerably influence the road traffic flow. For political reasons, priority could be given to pedestrians. A larger number of crossings reduces the pedestrian load per crossing and facilitates both the pedestrian flow and the car flow; the ultimate case is a “cross anywhere”
Knoop, V.L. (author), Daganzo, Carlos F. (author)   +1 more
openaire   +2 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Traffic State Spatial-Temporal Characteristic Analysis and Short-Term Forecasting Based on Manifold Similarity

IEEE Access, 2018
The study on the spatial-temporal characteristics of highway traffic flow is helpful to deeply understand the inherent evolution of highway traffic system and provide a theoretical basis for prediction and control of highway traffic flow.
Qingchao Liu, Yingfeng Cai, Haobin Jiang, Xiaobo Chen, Jian Lu   +4 more
doaj   +1 more source