Results 51 to 60 of about 144,271 (315)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Bill It Right: Evaluating Public Charging Station Usage Behavior under the Presence of Different Pricing Policies

World Electric Vehicle Journal
This study investigates for the first time how public charging infrastructure usage differs under the presence of diverse pricing models. About 3 million charging events from different European countries were classified according to five different ...
Markus Fischer, Wibke Michalk, Cornelius Hardt, Klaus Bogenberger   +3 more
doaj   +1 more source

Latent Heat of a Traffic Model

, 2013
We have studied the optimal velocity model (Bando et al., Jpn J Indust Appl Math 11:203, 1994; Phys Rev E 51:1035, 1995; J Phys I Fr 5:1389, 1995) for highway traffic. On a microscopic level, traffic flow is described by Bando's optimal velocity model in
Mahnke, Reinhard,, Hans Weber, Weber, Hans,, Reinhard Mahnke   +3 more
core   +1 more source

Multi-lane Traffic Flow Model: Speed Versus Density Difference as Lane Change Incentive and Effect of Lateral Flow Transfer on Traffic Flow Variables

, 2020
For better and more efficient motorway traffic control strategies on a lane level, accurate modelling and prediction of traffic conditions is essential. Existing real-time traffic state estimation methods aggregate traffic across lanes. Hence, there is a
van Arem, B. (author), Knoop, V.L. (author), Nagalur Subraveti, H.H.S. (author)   +2 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Trajectory Pattern Recognition in a Multi‐Airport Systems Based on a New 3D Multi‐Feature Trajectory Compression

IET Intelligent Transport Systems
With the rapid development of the global aviation industry, multi‐airport systems have emerged as a critical component of large urban clusters and regional aviation networks.
Ligang Yuan, Wenlu Chen, Haiyan Chen, Bin Wang, Xinding Zhou   +4 more
doaj   +1 more source

Traffic Flow Optimization on Roundabouts [PDF]

Procedia - Social and Behavioral Sciences, 2014
The aim of this article is to propose an optimization strategy for traffic flowon roundabouts using amacroscopic approach. The roundabout is modeled as a sequence of 2 × 2 junctions with one main lane and secondary incoming and outgoing roads. We consider two cost functionals: the total travel time and the total waiting time, which give an estimate of ...
Obsu, Legesse Lemecha, Delle Monache, Maria Laura, Goatin, Paola, Kassa, Semu Mitiku   +3 more
openaire   +3 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Traffic State Spatial-Temporal Characteristic Analysis and Short-Term Forecasting Based on Manifold Similarity

IEEE Access, 2018
The study on the spatial-temporal characteristics of highway traffic flow is helpful to deeply understand the inherent evolution of highway traffic system and provide a theoretical basis for prediction and control of highway traffic flow.
Qingchao Liu, Yingfeng Cai, Haobin Jiang, Xiaobo Chen, Jian Lu   +4 more
doaj   +1 more source