Results 121 to 130 of about 4,055,099 (393)
Advanced Science, EarlyView.Patch‐clamp experiments are fundamental to the measurement and understanding of ion currents that underlie physiological functions from neural activity to muscle contraction. Via a mathematical model of the experimental apparatus, this article highlights how artifact effects can be as large as some reported mutation and drug effects, and enables ...
Chon Lok Lei +8 more
wiley +1 more source
Direct numerical simulation of supersonic boundary layer transition induced by gap-type roughness
Advances in AerodynamicsThe transition of the supersonic boundary layer induced by roughness is a highly intricate process. Gaining a profound understanding of the transition phenomena and mechanisms is crucial for accurate prediction and control.
Hongkang Liu +5 more
doaj +1 more source
Advanced Science, EarlyView.This study revealed that adiponectin facilitates the therapeutic efficiency of thrombopoietic agents by stimulating the membrane trafficking of c‐Mpl in MKs, which provides a point for ITP therapy. Moreover, a novel c‐Mpl trafficking mechanism based on the Myosin‐9/Rab6A complex is constructed. These findings provide new insights into the applicability
Xin Zhao +8 more
wiley +1 more source
Driver Safety Public Opinion Poll [PDF]
, 2017 The overall objective of this research is to provide the National Safety Council with an understanding of attitudes and behaviors of the driving public across a variety of driver safety-related issues.Results from this research will be used to develop ...
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Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery
Advanced Science, EarlyView.Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang +5 more
wiley +1 more source
Problems for Vulnerable Road Users in Great Britain [PDF]
, 1989 INTRODUCTION In Britain pedal cycle and, in particular, pedestrian travel are important transport modes for the population. However, given the vulnerable nature of these modes of transport, the number of accidents involving pedestrians and cyclists is
Carsten, O.M.J. +2 more
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Advanced Science, EarlyView.This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv +8 more
wiley +1 more source
Effect of valve on ballistic performance in supercritical CO2 pneumatic launch
Journal of CO2 Utilization, 2023 To investigate the impact of the launch valve on the performance of the supercritical CO2 pneumatic launch, a numerical model was developed based on the principles of mass and energy conservation. Specifically, the thermos-physical properties of real gas
Jiaqiang Wang +4 more
doaj
Advanced Science, EarlyView.ICAM1 antibody‐bound ICG triggers tumor‐specific, caspase‐1‐independent pyroptosis via CTSS‐mediated GSDMD cleavage, activates antitumor immunity, and synergizes with anti–PD‐1 therapy, offering a non‐apoptotic strategy to overcome resistance in cancer treatment.
Fan Chen +17 more
wiley +1 more source