Results 121 to 130 of about 839,166 (302)

Safety and Systems Analysis, With Applications to Traffic Safety [PDF]

, 1968
Boodman, David M.
core   +2 more sources

Book Review [PDF]

, 1992
Review of the following: LEONARD EVANS, TRAFFIC SAFETY AND THE DRIVER. (Van Nostrand Reinhold 1991) [404 pp.] About the author, author index, figures, notes, preface, subject index, tables. LC 90-44233, ISBN 0-4421-00163-0. [Cloth $51.95. P.O.B.
Wheatcraft, Allan M.
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Direct numerical simulation of supersonic boundary layer transition induced by gap-type roughness

Advances in Aerodynamics
The transition of the supersonic boundary layer induced by roughness is a highly intricate process. Gaining a profound understanding of the transition phenomena and mechanisms is crucial for accurate prediction and control.
Hongkang Liu, Kehui Peng, Yatian Zhao, Qian Yu, Zhiqiang Kong, Jianqiang Chen   +5 more
doaj   +1 more source

Liposomal Nanoconfinement Enables Type I Photodynamic Conversion for Synergistic Cancer Photothermal‐Immunotherapy

Advanced Science, EarlyView.
Liposomal nanoconfinement converts the hemicyanine photosensitizer RhM from Type‐II to Type‐I photodynamic therapy (PDT) while enhancing photothermal therapy (PTT). The RhM‐R837@Lip nanoassembly efficiently generates superoxide (O2•−) and hydroxyl radicals (•OH) to kill tumor cells and achieve tumor ablation.
Minglu Zhang, Shanshan Liang, Meng Wang, Tingfeng Zhang, Jinke Liu, Yuyuan Peng, Hao Fang, Lingna Zheng, Xiao He, Meng Wang, Luling Wu, Tony D. James, Wei Zhao, Bing Wang, Weiyue Feng   +14 more
wiley   +1 more source

Study of Snow Accumulation on a High-Speed Train’s Bogies Based on the Discrete Phase Model

Journal of Applied Fluid Mechanics, 2017
During winters, the high-speed train travels in the northern of China is struck by to the snow, ice and coldness, massive snow accumulating on the bogies.
F. Xie, J. Zhang, G. Gao, K. He, Y. Zhang, J. Wang, Y. Zhang   +6 more
doaj  

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Performance evaluation of pretrained deep learning architectures for railway passenger ride quality classification

Alexandria Engineering Journal
This study investigates the performance of pretrained Convolutional Neural Networks (CNNs) in predicting passenger ride comfort classes based on encoded acceleration signal images.
Aliyu Kasimu, Wei Zhou, Qingkai Meng, Yazhao Wang, Zhixin Wang, Qiang Zhang, Yong Peng   +6 more
doaj   +1 more source

Vaccine hesitancy was not shown to be associated with traffic safety or driver behavior. [PDF]

Front Public Health, 2023
Wilson J, Rinner C, Kone AP, Bosveld E.
europepmc   +1 more source