Advanced Science, EarlyView.Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang +9 more
wiley +1 more source
Original and Low-Cost ADS-B System to Fulfill Air Traffic Safety Obligations during High Power LIDAR Operation. [PDF]
Sensors (Basel), 2023 Peyrin F +3 more
europepmc +1 more source
Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors
Advanced Science, EarlyView.Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu +11 more
wiley +1 more source
Traffic safety knowledge gain of ambulance drivers after simulator-based training. [PDF]
BMC Med Educ, 2022 Prohn MJ, Herbig B.
europepmc +1 more source
Encoding Cumulation to Learn Perturbative Nonlinear Oscillatory Dynamics
Advanced Science, EarlyView.Weak nonlinearities critically shape the long term behavior of oscillatory systems but are difficult to identify from data. A data‐driven framework is introduced to infer governing equations of weakly nonlinear oscillators from sparse and noisy observations.
Teng Ma +5 more
wiley +1 more source
Assessing the impact of the national traffic safety campaign: a nationwide cohort study in Japan. [PDF]
BMJ Open, 2022 Nakao S +12 more
europepmc +1 more source
Multipiece rim/wheel matching chart: Guide to accepted interchangeability for U.S. manufacturers truck and bus rim and wheel components. [PDF]
, 1978 United States National Highway Traffic Safety Administration
core +1 more source
Advanced Science, EarlyView.We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang +14 more
wiley +1 more source
Metabolomics-based Sleepiness Markers for Risk Prevention and Traffic Safety (ME-SMART): a monocentric, controlled, randomized, crossover trial. [PDF]
Trials, 2023 Scholz M +6 more
europepmc +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source