Results 71 to 80 of about 839,166 (302)

COMPLIANCE TESTING OF IOWA’S SKID-MOUNTED SIGN DEVICE [PDF]

open access: yes, 1999
A wide variety of traffic control devices are used in work zones, some of which are nont ormally found on the roadside or in the traveled way outsideofthe work zones.
Faller, Ronald K.   +4 more
core   +1 more source

Bridge expansion joint in road transition curve: effects assessment on heavy vehicles [PDF]

open access: yes, 2017
Properly-designed road surfaces provide a durable surface on which traffic can pass smoothly and safely. In fact, the main causes that determine the structural decay of the pavement and its parts are the traffic loads.
Bonin   +10 more
core   +2 more sources

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

open access: yesAdvanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma   +5 more
wiley   +1 more source

The impacts of neighbourhood traffic management [PDF]

open access: yes, 2012
A major traffic-related problem faced by residents is speeding, which not only causes safety concerns, but also noise issues. Traffic calming is a much favoured traffic management tool employed by road controlling authorities to primarily reduce ...
David Daniel, Basil
core   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

open access: yesAdvanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji   +7 more
wiley   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

open access: yesAdvanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales   +11 more
wiley   +1 more source

Increasing resilience of ATM networks using traffic monitoring and automated anomaly analysis [PDF]

open access: yes, 2012
Systematic network monitoring can be the cornerstone for the dependable operation of safety-critical distributed systems. In this paper, we present our vision for informed anomaly detection through network monitoring and resilience measurements to ...
Johnson, Christopher W.   +2 more
core  

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

open access: yesAdvanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang   +13 more
wiley   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

open access: yesAdvanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre   +3 more
wiley   +1 more source

Problems for Vulnerable Road Users in Great Britain [PDF]

open access: yes, 1989
INTRODUCTION In Britain pedal cycle and, in particular, pedestrian travel are important transport modes for the population. However, given the vulnerable nature of these modes of transport, the number of accidents involving pedestrians and cyclists is
Carsten, O.M.J.   +2 more
core  

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