Results 41 to 50 of about 10,613 (255)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Hybrid traffic scheduling in time‐sensitive networking for the support of automotive applications

IET Communications
Time‐sensitive networking (TSN) is considered one of the most promising solutions to address real‐time scheduling in in‐vehicle network due to its capabilities for providing deterministic service.
Hongrui Nie, Yue Su, Weibo Zhao, Junsheng Mu   +3 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Context Aware Traffic Scheduling Algorithm for Power Distribution Smart Grid Network

IEEE Access, 2019
The emergence of smart grid poses technical challenges to the power distribution network because of the increasing data traffic resulting from diverse data applications.
N. A. M. Radzi, N. Suhaimy, W. S. H. M. W. Ahmad, A. Ismail, F. Abdullah, M. Z. Jamaludin, M. N. Zakaria   +6 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Downlink Traffic Scheduling with Contact Durations Awareness for Vehicular Infrastructures

International Journal of Distributed Sensor Networks, 2014
The vehicular infrastructures or roadside units (RSUs) in vehicular delay tolerant networks (VDTNs) can be used as the gateways of the distributed sensor networks.
Zhongjiang Yan, Bo Li
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Deterministic Transmission Scheduling Mechanism for Mixed Traffic Flows Towards Digital Twin Networks [PDF]

Jisuanji kexue
A deterministic transmission scheduling mechanism based on deep reinforcement learning under the digital twin architecture is proposed for the end-to-end transmission of mixed traffic flows in railway operation and maintenance scenarios,namely end-to-end
WANG Kewen, ZHANG Weiting, LIAO Peixi
doaj   +1 more source

RETRACTED ARTICLE: Hybrid traffic security shaping scheme combining TAS and CQSF of time-sensitive networks in smart grid

EURASIP Journal on Wireless Communications and Networking, 2023
The new intelligent factory introduces Time-Sensitive Network into industrial Ethernet to provide real time and deterministic guarantee communication for production system.
Hongting Zhai, Qingrui Zhang, Ruilin Tang, Yantong Zhang, Lili Sun, Qi Zhai, Ruochen Bian, Xinxin He   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source