Results 101 to 110 of about 1,719 (293)
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Trafficability of soils: Slope studies
, 2020 CORPS OF ENGINEERS, U. S. ARMY TRAFFICABILITY OF SOILS SLOPE STUDIES CONDUCTED FOR OFFICE OF THE CHIEF OF ENGINEERS RESEARCH AND DEVELOPMENT DIVISION RESTRICTED TECHNICAL MEMORANDUM NO.
Waterways Experiment Station (U.S.);
core
Threonine 348 regulates the subcellular localization of PTEN
FEBS Open Bio, EarlyView.Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley +1 more source
FEBS Open Bio, EarlyView.The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Forecasting trafficability of soils: Report no. 6, volume 1, airphoto approach
, 2014 FORECASTING TRAFFIC ABILITY OF SOILS AIRPHOTO APPROACH TECHNICAL MEMORANDUM NO. 3-331 Report 6 Volume I June 1963 U. S. Army Engineer Waterways Experiment Station CORPS OF ENGINEERS Viclcsburg, Mississippi FORECASTING TRAFFICABILITY OF SOILS AIRPHOTO ...
Waterways Experiment Station (U.S.);
core
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
Trafficability of soils: Effects of surface conditions on drawbar pull of a wheeled vehicle
, 2020 TECHNICAL MEMORANDUM NO. 3-240 TRAFFICABILITY OF SOILS Nineteenth Supplement EFFECTS OF SURFACE CONDITIONS ON DRAWBAR PULL OF A WHEELED VEHICLE by E. S. Rush, J. H. Robinson April 1971 TA7 ,W34 no. 3- 240 Suppl... 19 Sponsored by U. S.
United States. Army Materiel Command;
core
, 2014 This study investigated the extent of soil damage caused by field traffic associated with different levels of soil moisture deficit (SMD). The hybrid SMD model was used for computing temporal patterns of SMD which can be accurately predicted for a range ...
Vero, S. E. +3 more
core +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source