Results 11 to 20 of about 320,364 (261)

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

Molecular Neurodegeneration, 2019
Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases, including Alzheimer’s disease.
Zoë P. Van Acker, Marine Bretou, Wim Annaert   +2 more
doaj   +1 more source

The RNA surveillance proteins UPF1, UPF2 and SMG6 affect HIV-1 reactivation at a post-transcriptional level

Retrovirology, 2018
Background The ability of human immunodeficiency virus type 1 (HIV-1) to form a stable viral reservoir is the major obstacle to an HIV-1 cure and post-transcriptional events contribute to the maintenance of viral latency.
Shringar Rao, Raquel Amorim, Meijuan Niu, Abdelkrim Temzi, Andrew J. Mouland   +4 more
doaj   +1 more source

Disputes Emanating from the Infringement of Articles 74(3) and 83(3) and Optional Exception under Article 298(1)(a)(i) of the United Nations Convention on the Law of the Sea

Asian Journal of Law and Policy, 2022
Maritime delimitation, which ensures the jurisdiction exertion and effective use of maritime spaces of coastal States, never involves minimal efforts.
Quyen Mai Nguyen, Linh Thao Nguyen
doaj   +1 more source

Systems Approaches to Combating Wildlife Trafficking: Expanding Existing Frameworks to Facilitate Cross-Disciplinary Collaboration

Frontiers in Conservation Science, 2021
Wildlife trafficking is a complex conservation issue that threatens thousands of species around the world and, in turn, negatively affects biodiversity and human well-being.
Christine Browne, Emily M. Ronis, Jennifer R. B. Miller, Jennifer R. B. Miller, Yula Kapetanakos, Samantha Gibbs, Tatiana Hendrix, Daphne Carlson Bremer   +7 more
doaj   +1 more source

HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex

mBio, 2016
Stress granules (SGs) are dynamic accumulations of stalled preinitiation complexes and translational machinery that assemble under stressful conditions.
Alessandro Cinti, Valerie Le Sage, Marwan Ghanem, Andrew J. Mouland   +3 more
doaj   +1 more source

The Public Health Impact of Coronavirus Disease on Human Trafficking

Frontiers in Public Health, 2020
The global pandemic of severe acute respiratory syndrome coronavirus 2 exacerbates major risk factors for global human trafficking. Social isolation of families and severe economic distress amplify the risk of interpersonal violence, unemployment and ...
Jordan Greenbaum, Jordan Greenbaum, Hanni Stoklosa, Hanni Stoklosa, Laura Murphy, Laura Murphy   +5 more
doaj   +1 more source

Multiple Domains in the Kv7.3 C-Terminus Can Regulate Localization to the Axon Initial Segment

Frontiers in Cellular Neuroscience, 2020
The voltage-gated Kv7.2/Kv7.3 potassium channel is a critical regulator of neuronal excitability. It is strategically positioned at the axon initial segment (AIS) of neurons, where it effectively inhibits repetitive action potential firing.
Louise Leth Hefting, Elisa D’Este, Emil Arvedsen, Tau Benned-Jensen, Hanne Borger Rasmussen   +4 more
doaj   +1 more source

HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases

Scientific Reports, 2017
HIV-1 co-opts several host machinery to generate a permissive environment for viral replication and transmission. In this work we reveal how HIV-1 impacts the host translation and intracellular vesicular trafficking machineries for protein synthesis and ...
Alessandro Cinti, Valerie Le Sage, Miroslav P. Milev, Fernando Valiente-Echeverría, Christina Crossie, Marie-Joelle Miron, Nelly Panté, Martin Olivier, Andrew J. Mouland   +8 more
doaj   +1 more source

Complete structure of the bacterial flagellar hook reveals extensive set of stabilizing interactions

Nature Communications, 2016
The bacterial flagellar hook is made up of many copies of the protein FlgE. Here, the authors report the full structure of the hook from Campylobacter jejuni and show that its overall structure is different from that of the previously published filament.
Hideyuki Matsunami, Clive S. Barker, Young-Ho Yoon, Matthias Wolf, Fadel A. Samatey   +4 more
doaj   +1 more source

Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway

Viruses, 2016
The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors
Valerie Le Sage, Alessandro Cinti, Raquel Amorim, Andrew J. Mouland   +3 more
doaj   +1 more source