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Regulation of Viral Restriction by Post-Translational Modifications
Viruses, 2021 Intrinsic immunity is orchestrated by a wide range of host cellular proteins called restriction factors. They have the capacity to interfere with viral replication, and most of them are tightly regulated by interferons (IFNs).
Célia Chamontin +4 more
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West Nile Virus Restriction in Mosquito and Human Cells: A Virus under Confinement
Vaccines, 2020 West Nile virus (WNV) is an emerging neurotropic flavivirus that naturally circulates between mosquitoes and birds. However, WNV has a broad host range and can be transmitted from mosquitoes to several mammalian species, including humans, through ...
Marie-France Martin, Sébastien Nisole
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Retrovirology, 2019 Background Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression.
Shringar Rao +5 more
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BMC Biology, 2017 Background In a macro-molecular complex, any minor change may prove detrimental. For a supra-molecular nano-machine like the bacterial flagellum, which consists of several distinct parts with specific characteristics, stability is important.
Clive S. Barker +4 more
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Ricin Trafficking in Cells [PDF]
Toxins, 2015 The heterodimeric plant toxin ricin binds exposed galactosyls at the cell surface of target mammalian cells, and, following endocytosis, is transported in vesicular carriers to the endoplasmic reticulum (ER). Subsequently, the cell-binding B chain (RTB) and the catalytic A chain (RTA) are separated reductively, RTA embeds in the ER membrane and then ...
Robert A. Spooner, J. Michael Lord
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Conceptualizing Task Force Sustainability
Societies, 2023 In the anti-human trafficking movement, multi-disciplinary teams have emerged as a best practice for collaborating and coordinating efforts in combating human trafficking.
Jennifer Paul Ray
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Trafficking and cell migration [PDF]
Traffic, 2009 The migration of single cells and epithelial sheets is of great importance for gastrulation and organ formation in developing embryos and, if misregulated, can have dire consequences e.g. during cancer metastasis. A keystone of cell migration is the regulation of adhesive contacts, which are dynamically assembled and disassembled via endocytosis. Here,
Ulrich, F., Heisenberg, C.
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MAP4K4 regulates forces at cell–cell and cell–matrix adhesions to promote collective cell migration
Life Science Alliance, 2023 Using A431 carcinoma cells, the study shows that MAP4K4 coordinates cluster migration by regulating forces and stability of focal adhesions and adherens junctions, promoting cytoskeleton rearrangements. Collective cell migration is not only important for
Lara Elis Alberici Delsin +8 more
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Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes
Communications Biology, 2021 Ivashenka et al. report that galectin-3 (Gal3) binding to lactotransferrin drives its transcytosis in enterocytes. Such trafficking is Gal3- and glycosphingolipid-dependent, and Gal3 is found in clathrin-independent carriers.
Alena Ivashenka +13 more
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iScience, 2023 Summary: Chemotaxis drives diverse migrations important for development and involved in diseases, including cancer progression. Using border cells in the Drosophila egg chamber as a model for collective cell migration, we characterized the role of ...
Alison Boutet +2 more
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