Results 191 to 200 of about 318,672 (261)

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

LRBA organizes distinct vesicular trafficking systems in distal nephron segments for water and sodium conservation. [PDF]

Proc Natl Acad Sci U S A
Nagaoka K, Ando F, Fujiki T, Abolhassani H, Hara Y, Yanagawa H, Suzuki S, Sakamaki Y, Oikawa D, Kikuchi H, Mandai S, Mori Y, Mori T, Susa K, Sohara E, Hoshino A, Ito T, Arakawa Y, Sasahara Y, Yasuda S, Abe Y, Yasui M, Tokunaga F, Kanegane H, Uchida S.   +24 more
europepmc   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Functional Genomics Screening in <i>Chlamydomonas reinhardtii</i> Maps the Genetic Landscape of Tolerance to Paraquat and Diuron. [PDF]

Environ Sci Technol
Godec T, Bleker C, Stare K, Lukan T, Levak V, Tušek Žnidarič M, Betz A, Kosjek T, van Midden KP, Klemenčič M, Trenti F, Guella G, Sepčić K, Fauser F, Patena W, Jonikas MC, Kerenčič M, Eleršek T, Pietri M, Rodet T, Bren U, Jukić M, Lešnik S, Županič A.   +23 more
europepmc   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks. [PDF]

J Biol Chem
Llorente A, Arora GK, Loughran RM, Murad R, Maurya S, Crabtree S, Portillo B, Chapagain P, Huluka H, Eron S, Goodman K, Ye G, Blind RD, Emerling BM.   +13 more
europepmc   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Editorial: The role of trafficking in synaptic development, maintenance, and plasticity

Frontiers in Cellular Neuroscience
Frederic J. Hoerndli, Peri T. Kurshan, Victor Anggono   +2 more
doaj   +1 more source

Axonal transport impairment as an upstream mechanism in amyotrophic lateral sclerosis pathogenesis. [PDF]

Front Neurosci
Gabbay U.
europepmc   +1 more source