Results 21 to 30 of about 23,818 (267)
Tragično a transcendence: „Všechno zlé není tragické“
This text concentrates on the relationship of evil and tragedy in context of the book Von der Wahrheit (1947; On the Truth) by Karl Jaspers. In its first part, the essay describes a distinct way of understanding Kant’s ethical evil.
Tomášová, Pavlína
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Les « terroirs » maritimes revisités
The diverse forms of sea spaces’ socialization and coastal societies’spatialization is reflected in the wealth of words for designating the traditional property rights of the sea and its resources.
Marie-Christine Cormier-Salem +1 more
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Inhuman Humanity: On the Theater of Angela Di Maso
This article discusses Angela Di Maso’s theater, which is a reflection on contemporary society and aims to awaken audiences from social conformity and consumerism.
Andrea F. De Carlo, Angela Di Maso
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The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Translating whole‐genome doubling into precision medicine in cancer
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Tragedy, Solidarity, and Impartiality. The Meaning of Hannah Arendt’s Thinking for Our Narrational Identity [PDF]
The aim of the article is to outline the meaning of the tragic component of action in Hannah Arendt’s theory of politics, and to relate it to the problem of modern storytelling and historiography by means of the concepts of solidarity and impartiality ...
Paulina Sosnowska
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Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
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Tragedia, romanticismo y modernidad. Dioniso entre mito y religión
The essay intends to rebuild relations among romanticism, tragedy and modernity from the lessons of Manfred Frank: The coming God and God in exile. These texts allow us rethink the tragedy in modern Western culture, represented in the figure of Dionysus.
Naím Garnica
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Antigone’s Choice: Tragedy and philosophy from dialectic to aporia
Shaped by Hegel, philosophy’s approach to Antigone has always been firmly rooted in all the assumptions of realism, with proper, true-to-life, consistent, and plausible characters.
Magda Romanska
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