Results 21 to 30 of about 23,818 (267)

Tragično a transcendence: „Všechno zlé není tragické“

open access: yesFilosofický časopis, 2021
This text concentrates on the relationship of evil and tragedy in context of the book Von der Wahrheit (1947; On the Truth) by Karl Jaspers. In its first part, the essay describes a distinct way of understanding Kant’s ethical evil.
Tomášová, Pavlína
doaj   +1 more source

Les « terroirs » maritimes revisités

open access: yesRevue d'ethnoécologie, 2018
The diverse forms of sea spaces’ socialization and coastal societies’spatialization is reflected in the wealth of words for designating the traditional property rights of the sea and its resources.
Marie-Christine Cormier-Salem   +1 more
doaj   +1 more source

Inhuman Humanity: On the Theater of Angela Di Maso

open access: yesPamiętnik Teatralny, 2023
This article discusses Angela Di Maso’s theater, which is a reflection on contemporary society and aims to awaken audiences from social conformity and consumerism.
Andrea F. De Carlo, Angela Di Maso
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Tragedy, Solidarity, and Impartiality. The Meaning of Hannah Arendt’s Thinking for Our Narrational Identity [PDF]

open access: yesPhainomena, 2019
The aim of the article is to outline the meaning of the tragic component of action in Hannah Arendt’s theory of politics, and to relate it to the problem of modern storytelling and historiography by means of the concepts of solidarity and impartiality ...
Paulina Sosnowska
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Tragedia, romanticismo y modernidad. Dioniso entre mito y religión

open access: yesFranciscanum, 2016
The essay intends to rebuild relations among romanticism, tragedy and modernity from the lessons of Manfred Frank: The coming God and God in exile. These texts allow us rethink the tragedy in modern Western culture, represented in the figure of Dionysus.
Naím Garnica
doaj   +1 more source

Antigone’s Choice: Tragedy and philosophy from dialectic to aporia

open access: yesPerformance Philosophy, 2022
Shaped by Hegel, philosophy’s approach to Antigone has always been firmly rooted in all the assumptions of realism, with proper, true-to-life, consistent, and plausible characters.
Magda Romanska
doaj   +1 more source

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