Results 91 to 100 of about 167,856,267 (292)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

French Gratitude Train visitor

, 1950
Visitor to the French Gratitude Train looking at a display case of traditional French dolls. On the wall are posters for the Alsace and Savoie regions of France from the French National Railroad Society.

core  

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Improving Compliance With Institutional Performance on Train of Four Monitoring. [PDF]

J Educ Perioper Med, 2023
Santapuram P, Coker Fowler L, Garvey KV, McEvoy MD, Robertson A, Dunworth B, McCarthy K, Freundlich R, Allen BFS, Kertai MD.   +9 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

[News Clip: Boy killed by train]

, 1956
Video footage from the WBAP-TV station in Fort Worth, Texas, covering a news story about four-year-old Dwight Bernard Thomas who was hit by a train in a Dallas train yard.
WBAP-TV (Television station : Fort Worth, Tex.)
core  

Do the Monitoring of the Depth of Anesthesia and Neuromuscular Monitoring Have an Impact on the Quality of Recovery After General Anesthesia?

Acta Clinica Croatica
Postoperative recovery quality is a critical indicator of patient outcomes. Traditional assessments focus on vital signs, mobility, pain, and nausea, while modern approaches include muscle strength, emotional state, physical independence, and patient ...
Katarina Atlagić, Nataša Kovač, Tomislav Radočaj, Sabina Babić, Nikolina Vratan   +4 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Train scheduling with application to the UK rail network

, 2013
Nowadays, transforming the railway industry for better performance and making the best usage of the current capacity are the key issues in many countries.
Khosravi, Banafsheh
core   +1 more source