Results 141 to 150 of about 2,585,798 (346)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Scheduling Trains with Priorities : a no-wait blocking parallel-machine job-shop scheduling model

open access: yes, 2011
The paper investigates train scheduling problems when prioritised trains and non-prioritised trains are simultaneously traversed in a single-line rail network.
Kozan, Erhan   +3 more
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

open access: yesFEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura   +19 more
wiley   +1 more source

Railway timetabling from an operations research

open access: yes
In this paper we describe Operations Research (OR) models andtechniques that can be used for determining (cyclic) railwaytimetables. We discuss the two aspects of railway timetabling: ($i$)the determination of arrival and departure times of the trains ...
Kroon, L.G., Huisman, D., Maroti, G.
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

Applying Operations Research techniques to planning of train shunting

open access: yes
In this paper, we discuss a model-based algorithmic approach for supporting planners in the creation of shunt plans for passenger trains. The approach provides an example of a mathematical model and a corresponding solution approach for model based ...
Woudt, C. van 't   +3 more
core  

Topological Constraints in Periodic Train Scheduling

open access: yes, 2008
It is well known that many scheduling problems can be modeled as constraint optimization problems. The scheduling of train services can be considered as a problem subject to a number of constraints describing railway infrastructure, required train ...
L. Ingolotti   +5 more
core  

Resolution of Station Level Constraints in Train Unit Scheduling [PDF]

open access: yes, 2018
Train unit scheduling assigns vehicles to cover all trips of a fixed timetable satisfying seat demands at minimum operational costs. Solved as a network flow problem, train stations are simplified to single points where certain station operation ...
Lei, L   +3 more
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

The new Dutch timetable: The OR revolution

open access: yes
In December 2006, Netherlands Railways introduced a completely new timetable. Its objective was to facilitate the growth of passenger and freight transport on a highly utilized railway network, and improve the robustness of the timetable resulting in ...
Schrijver, A.   +8 more
core  

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