Results 71 to 80 of about 1,490,462 (300)

A comparison of circuit training and high intensity interval training for population health [PDF]

, 2012
Thesis (M.A.)--Boston UniversityIn the fast-paced lifestyle of modern-day society, people often feel overwhelmed by their list of things to do. It is no surprise then that a lot of people claim that they have "no time" to exercise.
Chan, Elizabeth
core   +1 more source

Exercise training and losartan improve endothelial function in heart failure rats by different mechanisms [PDF]

, 2013
Objectives. To investigate the mechanisms of losartan- and exercise training-induced improvements on endothelial dysfunction in heart failure. Design. Sprague-Dawley rats subjected to left coronary artery ligation inducing myocardial infarction and heart
Crozier I, Morten Andre Høydal, Ole Johan Kemi, Per Magnus Haram, Ulrik Wisløff, Øyvind Ellingsen   +5 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Block vs. Traditional Periodization of HIT: Two Different Paths to Success for the World’s Best Cross-Country Skier

Frontiers in Physiology, 2019
In short-term studies, block periodization of high-intensity training (HIT) has been shown to be an effective strategy that enhances performance and related physiological factors. However, long-term studies and detailed investigations of macro, meso, and
Guro Strøm Solli, Guro Strøm Solli, Espen Tønnessen, Øyvind Sandbakk   +3 more
doaj   +1 more source

Update on osteoarthritis part 1: current concepts and the relation to exercise [PDF]

, 2002
There appears to be an increased risk of lower limb osteoarthritis in participants of repetitive, high impact sports, and this is strongly associated with joint injury. There seems to be little risk associated with recreational running.
Conaghan, P.
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Upper-Body Muscular Endurance Training Improves Performance Following 50 min of Double Poling in Well-Trained Cross-Country Skiers

Frontiers in Physiology, 2017
This study investigated the effect of muscular endurance training on O2-cost and performance in double poling (DP) on a rollerski treadmill. Twenty-two well-trained cross-country skiers (31 ± 4 years, 77 ± 9 kg, 181 ± 8 cm, VO2max running: 64 ± 5 mL·kg−1·
Jørgen Børve, Steffen N. Jevne, Bjarne Rud, Thomas Losnegard   +3 more
doaj   +1 more source

Effects of Equal Volume But Different Plyometric Jump Training Intensities on Components of Physical Fitness in Physically Active Young Males [PDF]

, 2019
An 8-week single-blind randomized controlled trial was conducted to compare the effects of separate programs of equal volume, but different intensity, plyometric jump training (PJT), on physical fitness in healthy adults.
Andrade, Argus, Asadi, Balsalobre-Fernandez, Behm, Brumitt, de Villarreal, Ebben, Ebben, Ebben, Flanagan, Granacher, Hopkins, Hopkins, Lees, Markovic, Peng, Piper, Pueo, Radnor, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Randell, Read, Ronnestad, Saez-Saez de Villarreal, Sáez de Villarreal, Taube, Thomas, Trecroci, Van Lieshout, Young   +37 more
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Block Training With Moderate‐ or High‐Intensity Intervals Both Improve Endurance Performance in Well‐Trained Cyclists

European Journal of Sport Science
The purpose of this study was to compare the effects of a 1‐week block of moderate‐intensity interval training (MIT) and high‐intensity interval training (HIT) in well‐trained cyclists. Cyclists (♀ = 1; ♂ = 21; maximal oxygen uptake (V̇O2max) = 69.5 (6.0)
Bent R. Rønnestad, Ingvill Urianstad Odden, Kristoffer Schulz Solum, Anne Mette Rustaden, Håvard Hamarsland, Daniel Hammarström, Håvard Nygaard, Knut Sindre Mølmen   +7 more
doaj   +1 more source