Results 81 to 90 of about 1,490,462 (300)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Unaltered maximal power and submaximal performance correlates with an oxidative vastus lateralis proteome phenotype during tapering in male cyclists

Physiological Reports
Little is known on how a short‐term reduction of training volume changes muscle proteome and physiological parameters. We investigated the impact of halving training volume during regular training of cyclists on physiological parameters in relation to ...
Pieter deLange, Giuseppe Petito, Hannah L. Notbohm, Antonia Giacco, Giovanni Renzone, Elena Silvestri, Arianna Cuomo, Frank Suhr, Thorsten Schiffer, Jonas Zacher, Federica Cioffi, Rosalba Senese, Andrea Scaloni, Moritz Schumann, Wilhelm Bloch   +14 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Comparison of acute physiological responses between one long and two short sessions of moderate-intensity training in endurance athletes

Frontiers in Physiology
PurposeTo compare acute physiological responses and perceived training stress between one long and two short time- and intensity-matched sessions of moderate-intensity training in endurance athletes.MethodsFourteen male endurance athletes (VO2max: 69.2 ±
Rune Kjøsen Talsnes, Per-Øyvind Torvik, Knut Skovereng, Øyvind Sandbakk   +3 more
doaj   +1 more source

Aerobic Energy Expenditure and Intensity Prediction During a Specific Circuit Weight Training: a Pilot Study [PDF]

, 2010
During circuit weight training (CWT), workloads, index of intensity as well as estimation of energy expenditure (EE) have been under estimated. The aim of this study was to describe and evaluate physiological variables and gender related differences ...
Ana Belén Peinado Lozano, Carter, Díaz, Francisco Javier Calderón Montero, Glenmark, María Álvarez Sánchez, Pedro José Benito Peinado, Víctor Díaz Molina   +7 more
core   +5 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Effect of Body Position and Support Surface on the Postural Control Challenge During the Pallof Press Exercise: A Smartphone Accelerometer-Based Study

Medicina
Background and objectives: Although different variations of the Pallof press exercise are commonly performed in sports and fitness settings to increase core stability, the intensity/difficulty of these variations is unknown and therefore it is difficult ...
Casto Juan-Recio, Amaya Prat-Luri, Heidy Rondón-Espinosa, David Barbado, Francisco J. Vera-Garcia   +4 more
doaj   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

External Load in High-Level Tennis Training: Influence of Game-Specific Drills in Junior and Professional Players Across Playing Situations

Applied Sciences
This study explored the influence of game-specific on-court drills on external load in junior and professional male tennis players. Using wearable inertial technology, a total of 345 drills performed during a training microcycle were analyzed.
Francisco José Penalva-Salmerón, Miguel Crespo, Rafael Martínez-Gallego, Jesús Ramón-Llin, José Francisco Guzmán   +4 more
doaj   +1 more source