Results 11 to 20 of about 840,036 (267)

Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health

Communications Biology, 2022
A genome-wide association study on MRI cerebellar volume in the UK Biobank cohort identifies 30 loci with genome-wide significance that might be relevant to brain structure and cognitive function.
Elleke Tissink, Siemon C. de Lange, Jeanne E. Savage, Douglas P. Wightman, Christiaan A. de Leeuw, Kristen M. Kelly, Mats Nagel, Martijn P. van den Heuvel, Danielle Posthuma   +8 more
doaj   +1 more source

Rare variant aggregation in 148,508 exomes identifies genes associated with proxy dementia

Scientific Reports, 2023
Proxy phenotypes allow for the utilization of genetic data from large population cohorts to analyze late-onset diseases by using parental diagnoses as a proxy for genetic disease risk. Proxy phenotypes based on parental diagnosis status have been used in
Douglas P. Wightman, Jeanne E. Savage, Christiaan A. de Leeuw, Iris E. Jansen, Danielle Posthuma   +4 more
doaj   +1 more source

Correction to: Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments

Translational Psychiatry, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41398-021-01334 ...
Josefin Werme, Sophie van der Sluis, Danielle Posthuma, Christiaan A. de Leeuw   +3 more
doaj   +1 more source

Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments

Translational Psychiatry, 2021
Gene-environment interactions (GxE) are often suggested to play an important role in the aetiology of psychiatric phenotypes, yet so far, only a handful of genome-wide environment interaction studies (GWEIS) of psychiatric phenotypes have been conducted.
Josefin Werme, Sophie van der Sluis, Danielle Posthuma, Christiaan A. de Leeuw   +3 more
doaj   +1 more source

Trait-trait correlation.

, 2023
Different colors indicate the correlation level and the stars indicate the significant correlations after Bonferroni correction. a) Trait-trait correlation calculated from cell-disease associations in adult non-brain tissues.
Maor Sauler (10704568), Naftali Kaminski (27713), Daiwei Tang (12883199), Hongyu Zhao (4728), Louise V. Wain (7588511), Ming Chen (115604), Zihan Dong (3334086), Wei Liu (20030), Michael H. Cho (6856079), Biqing Zhu (8861003), Chen Lin (95910), Wenxuan Deng (14853814), Zhaolong Yu (11404632)   +12 more
core   +1 more source

Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

Nature Communications, 2020
Brain volume and intelligence have been previously found to have shared genetic etiology, but the specific common genetic signals have not been identified.
Philip R. Jansen, Mats Nagel, Kyoko Watanabe, Yongbin Wei, Jeanne E. Savage, Christiaan A. de Leeuw, Martijn P. van den Heuvel, Sophie van der Sluis, Danielle Posthuma   +8 more
doaj   +1 more source

Accuracy of multi-trait genomic selection using different methods [PDF]

, 2011
Background Genomic selection has become a very important tool in animal genetics and is rapidly emerging in plant genetics. It holds the promise to be particularly beneficial to select for traits that are difficult or expensive to measure, such as traits
Veerkamp Roel F, Calus, M.P.L., Roel F Veerkamp, Calus Mario PL, Veerkamp, R.F., Mario PL Calus   +5 more
core   +1 more source

Trait-trait relationship constraints for sequential path analysis.

, 2023
Trait-trait relationship constraints for sequential path analysis.
Laura Siles (8941835), Smita Kurup (127775), Peter J. Eastmond (11388689), Alexander Calderwood (16920478), Richard J. Morris (11129541)   +4 more
core   +1 more source

Calculation of multiple-trait sire reliability for traits included in a dairy cattle fertility index [PDF]

, 2004
The advent of genetic evaluations for fertility traits in the UK offers valuable information to farmers that can be used to control fertility problems and safeguard against involuntary culling.
Coffey, M.P., Coffey, M. P., Thompson, R., Banos, Georgios, Wall, E; id_orcid, Brotherstone, S., Wall, E., Woolliams, JA, Thompson, R, Coffey, MP, Banos, G., Woolliams, J. A., Woolliams, John, Banos, G; id_orcid, Brotherstone, S   +14 more
core   +1 more source

Genome editing in maize directed by CRISPR–Cas9 ribonucleoprotein complexes

Nature Communications, 2016
Genome editing in plants typically requires the expression of Cas9 and guide RNA from stably transformed plasmid DNA. Here, the authors show that successful editing can be achieved after delivery of the Cas9-guide RNA complex as a ribonucleoprotein to ...
Sergei Svitashev, Christine Schwartz, Brian Lenderts, Joshua K. Young, A. Mark Cigan   +4 more
doaj   +1 more source