Results 71 to 80 of about 1,061,883 (288)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Ship Trajectory Clustering Method Considering Navigation Behavior Sequences

Journal of Marine Science and Engineering
Existing ship trajectory clustering methods often overlook the impact of navigation behaviors (e.g., heading and speed variations) on clustering performance.
Shaxige Wu, Lihua Zhang, Yinfei Zhou, Shuai Wei, Changlin Chen   +4 more
doaj   +1 more source

Online Clustering of Trajectory Data Stream

2016 17th IEEE International Conference on Mobile Data Management (MDM), 2016
Movement tracking becomes ubiquitous in many applications, which raises great interests in trajectory data analysis and mining. Most existing approaches cluster the whole trajectories offline. This allows characterizing the past movements of the objects but not current patterns.
Ticiana L. Coelho da Silva, Karine Zeitouni, José Antônio Fernandes de Macêdo   +2 more
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A Two-Step Clustering Approach to Extract Locations from Individual GPS Trajectory Data

ISPRS International Journal of Geo-Information, 2016
High-accuracy location identification is the basis of location awareness and location services. However, because of the influence of GPS signal loss, data drift and repeated access in the individual trajectory data, the efficiency and accuracy of ...
Zhongliang Fu, Zongshun Tian, Yanqing Xu, Changjian Qiao   +3 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Trajectory pattern mining via clustering based on similarity function for transportation surveillance [PDF]

, 2016
Recently, surveillance on moving vehicles for traffic flow monitoring has emerging in rapid rate. A comprehensive traffic data, that is vehicle trajectory, is selected as reliable data for discovering the underlying pattern via trajectory mining.
Yeo Kiam Beng @ Abdul Noor, Teo, Kenneth Tze Kin, Choong, Mei Yeen, Chin, Renee Ka Yin, Mei Yeen Choong, Renee Ka Yin Chin, Kiam Beng Yeo, Kenneth Tze Kin Teo   +7 more
core   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Traffic Network Identification Using Trajectory Intersection Clustering

Aerospace, 2020
The current airspace route system consists mainly of pre-defined routes with a low number of intersections to facilitate air traffic controllers to oversee the traffic.
Ingrid Gerdes, Annette Temme
doaj   +1 more source