Results 71 to 80 of about 76,600 (295)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A Two-Step Clustering Approach to Extract Locations from Individual GPS Trajectory Data
ISPRS International Journal of Geo-Information, 2016 High-accuracy location identification is the basis of location awareness and location services. However, because of the influence of GPS signal loss, data drift and repeated access in the individual trajectory data, the efficiency and accuracy of ...
Zhongliang Fu +3 more
doaj +1 more source
Online Clustering of Trajectory Data Stream
2016 17th IEEE International Conference on Mobile Data Management (MDM), 2016 Movement tracking becomes ubiquitous in many applications, which raises great interests in trajectory data analysis and mining. Most existing approaches cluster the whole trajectories offline. This allows characterizing the past movements of the objects but not current patterns.
Ticiana L. Coelho da Silva +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Ship Trajectory Clustering Method Considering Navigation Behavior Sequences
Journal of Marine Science and EngineeringExisting ship trajectory clustering methods often overlook the impact of navigation behaviors (e.g., heading and speed variations) on clustering performance.
Shaxige Wu +4 more
doaj +1 more source
Traffic Network Identification Using Trajectory Intersection Clustering
Aerospace, 2020 The current airspace route system consists mainly of pre-defined routes with a low number of intersections to facilitate air traffic controllers to oversee the traffic.
Ingrid Gerdes, Annette Temme
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
In-DBMS Sampling-based Sub-trajectory Clustering
, 2017 In this paper, we propose an efficient in-DBMS solution for the problem of sub-trajectory clustering and outlier detection in large moving object datasets.
Nikos Pelekis +4 more
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source