Results 91 to 100 of about 309,612 (268)

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi   +19 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende   +26 more
wiley   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher   +10 more
wiley   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown   +6 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen   +7 more
wiley   +1 more source

Key Technologies and Understanding of Shale Gas Horizontal Well Drilling of Well JY10HF

open access: yesShiyou jixie, 2019
Well JY10HF is the first exploratory shale gas horizontal well in the Jinfoshan fault slope of Nanchuan. The developed fracture and cave, large dip angle and poor drillability make it easy to be faced with lost circulation, wellbore collapse, inclination
Fan Hua, Long Zhiping
doaj  

Key technologies and development trends of borehole trajectory control in China’s coal mining areas

open access: yesMeitan kexue jishu
China boasts abundant coal reserves, yet complex geological conditions and significant variations in coal seam occurrence pose challenges. As mining difficulty and safety risks increase, directional drilling technology has become increasingly critical in
Dongdong YANG   +4 more
doaj   +1 more source

Local controllability along a reference trajectory

open access: yesJournal of Mathematical Analysis and Applications, 1991
Local controllability along a reference trajectory of analytic and smooth affine single input control systems (without any a priori bounds on the control) is considered. The main purpose of the paper is to give a geometric proof of a version of the Hermes conjecture for local controllability along a reference trajectory previously proved for local ...
openaire   +1 more source

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