Results 61 to 70 of about 309,612 (268)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Trajectory Planning and Tracking Control of a Differential-Drive Mobile Robot in a Picture Drawing Application

Robotics, 2017
This paper proposes a method for trajectory planning and control of a mobile robot for application in picture drawing from images. The robot is an accurate differential drive mobile robot platform controlled by a field-programmable-gate-array (FPGA ...
Ching-Long Shih, Li-Chen Lin
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

DEVELOPMENT OF TRAJECTORY CONTROL SYSTEM FOR THE OMNIDIRECTIONAL MOBILE ROBOT [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2014
The article deals with a trajectory control system development for the omnidirectional mobile robot. This kind of robots gives the possibility to control separately each degree of freedom due to special design of the wheels, which greatly facilitates the
Y. A. Kapitanyuk, A. A. Kapitonov, S. A. Chepinsky   +2 more
doaj  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

TRAJECTORY CONTROL OF A SOLID BODY RELATIVE TO THE MOVABLE OBJECT [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2014
The paper deals with the problem of dynamic tracking of an external movable object. These problems arise when designing tracking control systems for unmanned aircrafts following ground movable objects. A dynamic model of a solid body in three-dimensional
Y. A. Kapitanyuk, D. A. Khvostov, S. A. Chepinsky   +2 more
doaj  

An Adaptive Method for Trajectory Control of manipulators

Transactions of the Society of Instrument and Control Engineers, 1981
Abstract For the purpose of controlling motions of a mechanical manipulator in a wide range of work space, an adaptive trajectory control method is proposed. The method can make the manipulator move smoothly regardless of any change of circumstances and track desired trajectories described by arbitrary task-oriented coordinates.
TAKEGAKI, Morikazu, ARIMOTO, Suguru
openaire   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

A Centralized Multi-Agent DRL-Based Trajectory Control Strategy for Unmanned Aerial Vehicle-Enabled Wireless Communications

IEEE Open Journal of Vehicular Technology
Unmanned aerial vehicles (UAVs) are becoming increasingly popular as mobile base stations due to their flexible deployment and low-cost features, particularly for emergency communications, traffic offloading, and terrestrial communications infrastructure
Getaneh Berie Tarekegn, Rong-Terng Juang, Belayneh Abebe Tesfaw, Hsin-Piao Lin, Huan-Chia Hsu, Robel Berie Tarekegn, Li-Chia Tai   +6 more
doaj   +1 more source