Results 91 to 100 of about 1,387,882 (283)
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
A Microscopic On-Ramp Model Based on Macroscopic Network Flows
Applied SciencesWhile macroscopic traffic flow models adopt a fluid dynamic description of traffic, microscopic traffic flow models describe the dynamics of individual vehicles.
Niklas Kolbe +4 more
doaj +1 more source
A Novel Approach for Online Car-Hailing Monitoring Using Spatiotemporal Big Data
IEEE Access, 2019 Car-hailing service has increasingly become popular and fundamentally changed the way people travel in the era of sharing economy. Although such service brings convenience to people's lives, it also causes safety and property concerns.
Tong Zhou +5 more
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Topological Path Planning in GPS Trajectory Data [PDF]
Sensors, 2016 This paper proposes a novel solution to the problem of computing a set of topologically inequivalent paths between two points in a space given a set of samples drawn from that space. Specifically, these paths are homotopy inequivalent where homotopy is a topological equivalence relation.
openaire +3 more sources
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Approximate trajectory data for missions to the major planets [PDF]
Contour charts and tables on trajectory data for missions to Jupiter, Saturn, Uranus, and Neptune and their ...
Fishbach, L. H. +2 more
core +1 more source