Results 91 to 100 of about 50,329,501 (342)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
An incremental lane-level network construction method based on high-precision trajectories
International Journal of Digital EarthLane-level network offers spatial references for autonomous driving, while trajectories remain crucial for their maintenance. However, prevailing methods exhibit limited ability in modeling network dynamics due to the intricate structure of traffic ...
Chuanwei Cai +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Indoor Pedestrian Trajectory Data and Indoor Structural Point Clouds Data
The dataset includes pedestrian trajectory data within a two-story indoor environment, as well as point cloud data of the indoor structure.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Lu, K (via Mendeley Data), Lu, Keyu
core +1 more source
Applied SciencesReal-time traffic safety analysis is necessary to determine proactive risks associated with traffic conflicts. This study presents a driving-risk detection framework based on high-precision naturalistic vehicle trajectory data to support host vehicle ...
Nusrath Tabassum +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
mttfst/trajectory-cross-section: paper version, prep for sample data
, 2020 The script draws a cross-section plot from any variable of an atmospheric model along a given trajectory.
Matthias Faust
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source