Results 81 to 90 of about 1,387,882 (283)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Road Passenger Load Probability Prediction and Path Optimization Based on Taxi Trajectory Big Data
Applied SciencesThis paper focuses on predicting road passenger probability and optimizing taxi driving routes based on trajectory big data. By utilizing clustering algorithms to identify key passenger points, a method for calculating and predicting road passenger ...
Guobin Gu +7 more
doaj +1 more source
Learning from history: Non-Markovian analyses of complex trajectories for extracting long-time behavior [PDF]
, 2014 A number of modern sampling methods probe long time behavior in complex biomolecules using a set of relatively short trajectory segments. Markov state models (MSMs) can be useful in analyzing such data sets, but in particularly complex landscapes, the ...
Suarez, Ernesto, Zuckerman, Daniel
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Real-time detection of traffic congestion based on trajectory data
The Journal of Engineering, 2019 Traffic congestion is common in most cities. It not only affects people's normal travel time but also causes more traffic crashes. To solve the traffic congestion and reduce the corresponding hazards, it is necessary to quickly detect the location of ...
Qing Yang +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Future TransportationIntersection safety has been traditionally evaluated using three to five years of crash data. Recent literature suggests that connected vehicle (CV)-derived hard braking (HB) events can provide a surrogate for crashes with only a few weeks or months of ...
Vihaan Vajpayee +3 more
doaj +1 more source
ISPRS International Journal of Geo-Information, 2017 Human activity hotspots are the clusters of activity locations in space and time, and a better understanding of their functionality would be useful for urban land use planning and transportation.
Tao Jia, Zheng Ji
doaj +1 more source