Results 111 to 120 of about 5,067,781 (348)

Effects of tranexamic acid on platelet function and thrombin generation (ETAPlaT): WOMAN trial sub-study. [PDF]

, 2016
Background. Postpartum haemorrhage (PPH) is a leading cause of maternal death. Tranexamic acid (TXA) has the potential to reduce bleeding and a large randomized placebo controlled trial of its effect in women with PPH (The WOMAN trial) is underway.
Beaumont, Danielle, Cenameri, Saimir, Dallaku, Kastriot, Delius, Maria, Edwards, Phil, Gliozheni, Orion, Mansmann, Ulrich, Roberts, Ian, Shakur, Haleema, Siegmund, Braun, Tasha, Ilir   +10 more
core   +2 more sources

Tranexamic Acid Inhibits Angiogenesis and Melanogenesis in Vitro by Targeting VEGF Receptors

International Journal of Medical Sciences, 2020
Melasma is a common but complex skin condition concerning cosmetic problems. Tranexamic acid (TA) has been proved to be effective in treatment of melasma with still unclear mechanisms. Here, we show that VEGF165 enhanced the expression of VEGF receptors (
Jian-wei Zhu, Ya-jie Ni, Xiao-Yun Tong, Xia Guo, Xiao-Ping Wu, Zhongfa Lu   +5 more
semanticscholar   +1 more source

Prevalence, Comorbidities, and Current Management of Chronic Spontaneous Urticaria in Japan: Retrospective Claims Database Study

The Journal of Dermatology, EarlyView.
ABSTRACT Chronic spontaneous urticaria (CSU) affects 0.5%–1.0% of the population worldwide. However, information on the prevalence, comorbidities, and treatment patterns of CSU in Japan is limited. This observational study consisted of a cross‐sectional and longitudinal part.
Atsushi Fukunaga, Yuko Kishi, Yoshinori Sunaga, Kazuhiko Arima   +3 more
wiley   +1 more source

Effect of oral tranexamic acid on macular edema associated with retinal vein occlusion or diabetes [PDF]

, 2017
Purpose: Tranexamic acid (TXA) is a widely used antifibrinolytic agent that can also cause a decrease in vascular permeability. We hypothesized that TXA could improve macular edema (ME) that is caused by an increase in retinal vascular permeability.
Gosho Masahiko, Iwaki Masayoshi, Kamei Motohiro, Sugita Keijiro, Takeuchi Fumio, Takeyama Masayuki, Zako Masahiro, 五所 正彦   +7 more
core   +3 more sources

The Effectiveness of Oxytocin for Preventing Postpartum Haemorrhage: An Individual Participant Data Meta‐Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Post‐partum haemorrhage (PPH) is a common complication of labour. Objective To assess the effectiveness of oxytocin in comparison to no treatment for preventing PPH. Selection Criteria Published and unpublished randomised controlled trials (RCTs) comparing systemic oxytocin to placebo or no intervention for preventing PPH were ...
Madeline Flanagan, Arsheeya Rattan, Ling Shan Au, Malitha Patabendige, Carole‐Anne Whigham, Suze Jans, Patience Cofie, G. Justus Hofmeyr, Leiv Arne Rosseland, Andrew Weeks, Wentao Li, Ben W. J. Mol   +11 more
wiley   +1 more source

A systematic review and meta-analysis of systematic and topical tranexamic acid administration in aesthetic plastic surgery

Perioperative Medicine
Introduction Tranexamic acid has been widely used in plastic surgery. However, its efficacy has yet to be fully established. This meta-analysis aimed to determine its effectiveness in aesthetic plastic surgery.
Jerzy Kolasiński, Tomasz Reysner, Małgorzata Kolenda, Szymon Kołacz, Małgorzata Domagalska   +4 more
doaj   +1 more source

Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review

Acta Dermato-Venereologica, 2017
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included.
Hyun Jung Kim, Seok Hoon Moon, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim   +4 more
doaj   +1 more source

Carbetocin for Postpartum Haemorrhage Prophylaxis in All Births: A Retrospective Cohort Study Following Policy Change in Routine Uterotonic Use

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To compare postpartum haemorrhage (PPH) outcomes following a change in routine prophylactic uterotonic from Oxytocin to Carbetocin. Design A retrospective cohort study with a before‐after design. Setting A large tertiary maternity service in Melbourne, Australia.
Megan McKimmie‐Doherty, Vidanka Vasilevski, Lauren De Luca, Elisa McDonald, Tracey Grainger, Lucy Nash, Linda Sweet   +6 more
wiley   +1 more source

Tranexamic acid decreases rodent hemorrhagic shock-induced inflammation with mixed end-organ effects.

PLoS ONE, 2018
Beyond its anti-fibrinolytic mechanism, tranexamic acid has been suggested to have anti-inflammatory properties which may contribute to the survival benefit it provides to trauma patients.
Patrick F Walker, Anthony D Foster, Philip A Rothberg, Thomas A Davis, Matthew J Bradley   +4 more
doaj   +1 more source

Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial. [PDF]

, 2014
INTRODUCTION: To investigate the mechanism of action of tranexamic acid (TXA) in bleeding trauma patients, we examined the timing of its effect on mortality.
Manno, Daniela, Prieto-Merino, David, Roberts, Ian   +2 more
core   +1 more source