Results 11 to 20 of about 5,067,781 (348)

The Use of Tranexamic Acid in Dermatology

Acta Clinica Croatica, 2023
Tranexamic acid is a synthetic derivative of the amino acid lysine, an antifibrinolytic that is primarily used to reduce bleeding in surgery, trauma, and dental procedures. Its anti-inflammatory and anti-angiogenic properties, as well as its ability to suppress melanogenesis have enabled it to be used in dermatology in the treatment of skin conditions ...
Gaćina, Klara, Krstanović Ćosić, Anđela   +1 more
openaire   +4 more sources

Prehospital tranexamic acid for trauma victims

Journal of Intensive Care, 2023
The public enquiry into the mass casualty incident at the Manchester Arena in the UK in which 23 people died and over 1000 were injured, identified the need for timely intramuscular administration of tranexamic acid to trauma patients.
Kazuhiko Omori, Ian Roberts
doaj   +2 more sources

Efficacy and Safety of Tranexamic Acid in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Frontiers in Surgery, 2022
Tranexamic acid has been shown to reduce rebleeding after aneurysmal subarachnoid hemorrhage; however, whether it can reduce mortality and improve clinical outcomes is controversial.
Min Shi, Chao Yang, Zu-han Chen, Ling-fei Xiao, Wen-yuan Zhao   +4 more
doaj   +2 more sources

Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo-controlled trial

Stroke and Vascular Neurology, 2021
Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial haemorrhage. We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral ...
Liping Liu, Yuehua Pu, Yongjun Wang, Yan Wang, Xingquan Zhao, Hongqiu Gu, Qi Zhou, Yibin Cao, Wenzhi Wang, Dacheng Liu, Jingyi Liu, Haixin Sun, Zhonghua Yang, Ximing Nie, Miao Wen, Shengjun Sun, Ying Tan, Lina Zheng, Jiahui Zhao, Haomeng Zhu, Yunpeng Zhang, Lijin Yi   +21 more
doaj   +2 more sources

Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery.

New England Journal of Medicine, 2023
BACKGROUND Prophylactic use of tranexamic acid at the time of cesarean delivery has been shown to decrease the calculated blood loss, but the effect on the need for blood transfusions is unclear.
L. Pacheco, R. Clifton, G. Saade, Steven J. Weiner, S. Parry, J. Thorp, M. Longo, A. Salazar, W. Dalton, Alan T N Tita, C. Gyamfi‐Bannerman, S. Chauhan, T. Metz, K. Rood, D. Rouse, J. Bailit, W. Grobman, H. Simhan, G. Macones   +18 more
semanticscholar   +1 more source

Tranexamic acid in melasma: A focused review on drug administration routes

Journal of Cosmetic Dermatology, 2023
Melasma is a disorder of hyperpigmentation and vascularization often found in women between the ages of 20 and 40. The pathogenesis is unknown, but melasma often occurs in sun‐exposed areas of the face, forearms, and back.
Hailey Konisky, Eliza Balazic, J. Jaller, Urmi Khanna, K. Kobets   +4 more
semanticscholar   +1 more source

Tranexamic acid for haemostasis and beyond: does dose matter?

Thrombosis Journal, 2023
Tranexamic acid (TXA) is a widely used antifibrinolytic agent that has been used since the 1960’s to reduce blood loss in various conditions. TXA is a lysine analogue that competes for the lysine binding sites in plasminogen and tissue-type plasminogen ...
Tammy Lam, R. Medcalf, Geoffrey C. Cloud, Paul S Myles, Charithani B. Keragala   +4 more
semanticscholar   +1 more source

Prophylactic intravenous tranexamic acid and thromboembolism in non-cardiac surgery: a systematic review, meta-analysis and trial sequential analysis.

Anaesthesia, 2023
Tranexamic acid is an antifibrinolytic drug that is widely used during surgery, but there are concerns about its thromboembolic effects. We aimed to investigate the effect of prophylactic intravenous tranexamic acid on thromboembolic outcomes in patients
S. E. H. Tsan, N. L. Viknaswaran, C. C. Cheong, S. Cheah, K. Ng, S. Mong, C. Y. Wang   +6 more
semanticscholar   +1 more source

Tranexamic Acid in Patients Undergoing Noncardiac Surgery.

New England Journal of Medicine, 2022
BACKGROUND Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding.
P. Devereaux, M. Marcucci, T. Painter, D. Conen, V. Lomivorotov, D. Sessler, M. Chan, F. Borges, M. Martínez-Zapata, Chew-Yin Wang, Denis Xavier, S. Ofori, M. Wang, S. Efremov, G. Landoni, Y. Kleinlugtenbelt, W. Szczeklik, D. Schmartz, A. Garg, T. Short, M. Wittmann, C. Meyhoff, M. Amir, David Torres, Ameen Patel, E. Duceppe, K. Ruetzler, J. Parlow, V. Tandon, E. Fleischmann, C. Polanczyk, A. Lamy, S. Astrakov, Mangala Rao, William K K Wu, K. Bhatt, M. de Nadal, V. Likhvantsev, P. Paniagua, H. Aguado, R. Whitlock, M. McGillion, M. Prystajecky, J. Vincent, J. Eikelboom, I. Copland, K. Balasubramanian, A. Turan, S. Bangdiwala, David Stillo, Peter Gross, T. Cafaro, P. Alfonsi, P. Roshanov, E. Belley‐Cote, J. Spence, T. Richards, T. Vanhelder, William L. McIntyre, G. Guyatt, S. Yusuf, K. Leslie   +61 more
semanticscholar   +1 more source

Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery: The OPTIMAL Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2022
Importance Tranexamic acid is recommended for reducing blood loss and transfusion in cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid provides better blood-sparing effect than a low dose without increasing the risk of ...
Jia Shi, Chenghui Zhou, W. Pan, Hansong Sun, Sheng Liu, W. Feng, Weijian Wang, Zhaoyun Cheng, Yang Wang, Zhe Zheng   +9 more
semanticscholar   +1 more source