Results 11 to 20 of about 5,005,447 (264)

Tranexamic Acid in Patients Undergoing Noncardiac Surgery.

New England Journal of Medicine, 2022
BACKGROUND Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding.
P. Devereaux, M. Marcucci, T. Painter, D. Conen, V. Lomivorotov, D. Sessler, M. Chan, F. Borges, M. Martínez-Zapata, Chew-Yin Wang, Denis Xavier, S. Ofori, M. Wang, S. Efremov, G. Landoni, Y. Kleinlugtenbelt, W. Szczeklik, D. Schmartz, A. Garg, T. Short, M. Wittmann, C. Meyhoff, M. Amir, David Torres, Ameen Patel, E. Duceppe, K. Ruetzler, J. Parlow, V. Tandon, E. Fleischmann, C. Polanczyk, A. Lamy, S. Astrakov, Mangala Rao, William K K Wu, K. Bhatt, M. de Nadal, V. Likhvantsev, P. Paniagua, H. Aguado, R. Whitlock, M. McGillion, M. Prystajecky, J. Vincent, J. Eikelboom, I. Copland, K. Balasubramanian, A. Turan, S. Bangdiwala, David Stillo, Peter Gross, T. Cafaro, P. Alfonsi, P. Roshanov, E. Belley‐Cote, J. Spence, T. Richards, T. Vanhelder, William L. McIntyre, G. Guyatt, S. Yusuf, K. Leslie   +61 more
semanticscholar   +1 more source

Trauma and tranexamic acid [PDF]

Medical Journal of Australia, 2013
Research is needed to determine how patient selection and intercurrent treatment affect safety and efficacyClinicians involved in the resuscitation of severely injured patients face a dilemma. On one hand, since publication of the landmark CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage 2) study in 2010, there has been
Gruen, Russell L., Jacobs, Ian G., Reade, Michael C.   +2 more
openaire   +4 more sources

Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery: The OPTIMAL Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2022
Importance Tranexamic acid is recommended for reducing blood loss and transfusion in cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid provides better blood-sparing effect than a low dose without increasing the risk of ...
Jia Shi, Chenghui Zhou, W. Pan, Hansong Sun, Sheng Liu, W. Feng, Weijian Wang, Zhaoyun Cheng, Yang Wang, Zhe Zheng   +9 more
semanticscholar   +1 more source

Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression.

JAMA Surgery, 2021
Importance Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns remain about the potential adverse effects, particularly vascular occlusive events, that may be associated with its use.
Isabel Taeuber, S. Weibel, E. Herrmann, Vanessa Neef, T. Schlesinger, P. Kranke, Leila Messroghli, K. Zacharowski, S. Choorapoikayil, P. Meybohm   +9 more
semanticscholar   +1 more source

Update on Applications and Limitations of Perioperative Tranexamic Acid

Anesthesia and Analgesia, 2022
Tranexamic acid (TXA) is a potent antifibrinolytic with documented efficacy in reducing blood loss and allogeneic red blood cell transfusion in several clinical settings.
Prakash A. Patel, J. Wyrobek, A. Butwick, E. Pivalizza, G. Hare, C. Mazer, S. Goobie   +6 more
semanticscholar   +1 more source

The Use of Tranexamic Acid in Dermatology

Acta Clinica Croatica, 2023
Tranexamic acid is a synthetic derivative of the amino acid lysine, an antifibrinolytic that is primarily used to reduce bleeding in surgery, trauma, and dental procedures. Its anti-inflammatory and anti-angiogenic properties, as well as its ability to suppress melanogenesis have enabled it to be used in dermatology in the treatment of skin conditions ...
Klara Gaćina, Anđela Krstanović Ćosić   +1 more
openaire   +3 more sources

Association of Tranexamic Acid Administration With Mortality and Thromboembolic Events in Patients With Traumatic Injury

JAMA Network Open, 2022
Key Points Question Is the administration of tranexamic acid associated with mortality and thromboembolic events in patients with traumatic injury? Findings This systematic review and meta-analysis included 31 randomized clinical trials and observational
V. Karl, S. Thorn, T. Mathes, S. Hess, M. Maegele   +4 more
semanticscholar   +1 more source

Safety and Efficacy of Local Tranexamic Acid for the Prevention of Surgical Bleeding in Soft-Tissue Surgery: A Review of the Literature and Recommendations for Plastic Surgery

Plastic and Reconstructive Surgery, 2022
Background: Although high-bleed surgery routinely utilizes the antifibrinolytic drug tranexamic acid, most plastic surgical procedures are conducted in soft tissue with low-volume bleeding.
Kjersti Ausen, R. Fossmark, O. Spigset, H. Pleym   +3 more
semanticscholar   +1 more source

The effect of Tranexamic acid on cardiac surgery bleeding [PDF]

Reviews in Clinical Medicine, 2014
Serious bleeding in cardiac surgery leads to re-exploration, blood transfusion and increases the risks of mortality and morbidity. Using the lysine analogous of antifibrionlytic agents are the preferred strategy to suppress the need for transfusion ...
Mohammad Esmaeelzadeh, Shahram Amini
doaj   +3 more sources

The effect of tranexamic acid in patients with TBI: a systematic review and meta-analysis of randomized controlled trials

Chinese Neurosurgical Journal, 2020
To conduct a systematic review and meta-analysis and evaluate the effect of tranexamic acid in patients with traumatic brain injury. PubMed, EMBASE, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched to identify randomized ...
Chao-nan Du, Bo-xue Liu, Qing-fang Ma, Ming-fei Yang   +3 more
doaj   +1 more source