Chinese Neurosurgical Journal, 2020 To conduct a systematic review and meta-analysis and evaluate the effect of tranexamic acid in patients with traumatic brain injury. PubMed, EMBASE, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched to identify randomized ...
Chao-nan Du +3 more
doaj +1 more source
Comparative Study of Two Different Intravenous Doses of Tranexamic Acid with Placebo on Surgical Field Quality in Functional Endoscopic Sinus Surgery-A Randomised Clinical Trial [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: Intraoperative haemorrhage, which disrupts surgical patency, is a major obstacle for surgeons, especially in endoscopic sinus surgeries. Tranexamic acid is synthetic antifibrinolytic agent that binds competitively at lysine binding site on ...
Tamil Anbu Pannerselvam +2 more
doaj +1 more source
Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial. [PDF]
, 2011 OBJECTIVE: To assess the cost effectiveness of giving tranexamic acid (TXA) to bleeding trauma patients in low, middle and high income settings. METHODS: The CRASH-2 trial showed that TXA administration reduces the risk of death in bleeding trauma ...
Shakur Haleema +16 more
core +1 more source
Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid - a meta-analysis of randomised and observational trials of over 30.000 patients [PDF]
, 2013 Background: To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.
Meybohm, Patrick +11 more
core +1 more source
Bulletin de la Dialyse à Domicile, 2021 Chronic kidney disease patients experience not only more frequent arterial and venous thrombosis but also hemorrhagic episodes. Tranexamic acid is an anti-fibrinolytic molecule that inhibits plasmin activation.
Elodie Bogner +3 more
doaj +1 more source
The effect of Tranexamic acid on cardiac surgery bleeding [PDF]
Reviews in Clinical Medicine, 2014 Serious bleeding in cardiac surgery leads to re-exploration, blood transfusion and increases the risks of mortality and morbidity. Using the lysine analogous of antifibrionlytic agents are the preferred strategy to suppress the need for transfusion ...
Mohammad Esmaeelzadeh, Shahram Amini
doaj +3 more sources
Use of Tranexamic Acid during Total Endoprosthetic Replacement of the Hip Joint
Общая реаниматология, 2010 Objective: to evaluate the blood-saving activity, efficacy, and safety of tranexamic acid. Subjects and methods. Thirty-seven patients allocated into two groups were enrolled in the study of the efficacy of tranexamic acid as an agent in reducing blood ...
D. D. Selivanov +4 more
doaj +1 more source
Intravenous tranexamic acid as an adjunct haemostat to ornipressin during open myomectomy. A randomized double blind placebo controlled trial [PDF]
, 2015 Myomectomy is a surgical technique used for removal of uterine fibroids and historically hysterectomy has represented the mainstay of treatment. The options of conservative surgical approaches mainly aim at retention of fertility but have to be balanced ...
Ngichabe, Sammy +5 more
core +1 more source
Trials, 2022 Background The prophylactic administration of tranexamic acid reduces blood loss during procedures at high risk of perioperative bleeding. Several studies in cardiac surgery and orthopedics confirmed this finding.
M. Balik +5 more
doaj +1 more source
Efficiency of Cardiotropic Therapy in Neonatal Infants with Posthypoxic Myocardial Damage
Общая реаниматология, 2011 Objective: to define the optimal tranexamic acid dosage regimen to reduce perioperative blood loss during total endo-prosthetic hip joint replacement (TEHJR). Subjects and methods.
Yu. N. Belova +2 more
doaj +1 more source