Results 21 to 30 of about 5,120,986 (304)

THE USE OF TRANEXAMIC ACID IN DERMATOLOGY

Acta Clinica Croatica, 2023
SUMMARY Tranexamic acid is a synthetic derivative of the amino acid lysine, an antifibrinolytic that is primarily used to reduce bleeding in surgery, trauma, and dental procedures.
Klara Gaćina, Anđela Krstanović Ćosić   +1 more
semanticscholar   +1 more source

Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery: The OPTIMAL Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2022
Importance Tranexamic acid is recommended for reducing blood loss and transfusion in cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid provides better blood-sparing effect than a low dose without increasing the risk of ...
Jia Shi, Chenghui Zhou, W. Pan, Hansong Sun, Sheng Liu, W. Feng, Weijian Wang, Zhaoyun Cheng, Yang Wang, Zhe Zheng   +9 more
semanticscholar   +1 more source

Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression.

JAMA Surgery, 2021
Importance Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns remain about the potential adverse effects, particularly vascular occlusive events, that may be associated with its use.
Isabel Taeuber, S. Weibel, E. Herrmann, Vanessa Neef, T. Schlesinger, P. Kranke, Leila Messroghli, K. Zacharowski, S. Choorapoikayil, P. Meybohm   +9 more
semanticscholar   +1 more source

Update on Applications and Limitations of Perioperative Tranexamic Acid

Anesthesia and Analgesia, 2022
Tranexamic acid (TXA) is a potent antifibrinolytic with documented efficacy in reducing blood loss and allogeneic red blood cell transfusion in several clinical settings.
Prakash A. Patel, J. Wyrobek, A. Butwick, E. Pivalizza, G. Hare, C. Mazer, S. Goobie   +6 more
semanticscholar   +1 more source

Tranexamic acid: Beyond antifibrinolysis

Transfusion, 2022
Tranexamic acid (TXA) is a popular antifibrinolytic drug widely used in hemorrhagic trauma patients and cardiovascular, orthopedic, and gynecological surgical patients. TXA binds plasminogen and prevents its maturation to the fibrinolytic enzyme plasmin.
I. Prudovsky, Doreen Kacer, V. Zucco, M. Palmeri, C. Falank, Robert Kramer, D. Carter, J. Rappold   +7 more
semanticscholar   +1 more source

Association of Tranexamic Acid Administration With Mortality and Thromboembolic Events in Patients With Traumatic Injury

JAMA Network Open, 2022
Key Points Question Is the administration of tranexamic acid associated with mortality and thromboembolic events in patients with traumatic injury? Findings This systematic review and meta-analysis included 31 randomized clinical trials and observational
V. Karl, S. Thorn, T. Mathes, S. Hess, M. Maegele   +4 more
semanticscholar   +1 more source

Prophylactic tranexamic acid in patients with hematologic malignancy: a placebo-controlled, randomized clinical trial

Blood, 2022
The antifibrinolytic agent tranexamic acid (TXA) is often used to prevent bleeding in patients with hemorrhagic disorders or platelet dysfunction, and there has been speculation that it might prevent bleeding in patients with thrombocytopenia ...
T. Gernsheimer, Siobhan P. Brown, D. Triulzi, N. Key, N. El Kassar, H. Herren, Jacqueline N. Poston, M. Boyiadzis, B. Reeves, Subodh Selukar, M. Pagano, S. Emerson, S. May   +12 more
semanticscholar   +1 more source

The effect of tranexamic acid in patients with TBI: a systematic review and meta-analysis of randomized controlled trials

Chinese Neurosurgical Journal, 2020
To conduct a systematic review and meta-analysis and evaluate the effect of tranexamic acid in patients with traumatic brain injury. PubMed, EMBASE, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched to identify randomized ...
Chao-nan Du, Bo-xue Liu, Qing-fang Ma, Ming-fei Yang   +3 more
doaj   +1 more source

Comparative Study of Two Different Intravenous Doses of Tranexamic Acid with Placebo on Surgical Field Quality in Functional Endoscopic Sinus Surgery-A Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Intraoperative haemorrhage, which disrupts surgical patency, is a major obstacle for surgeons, especially in endoscopic sinus surgeries. Tranexamic acid is synthetic antifibrinolytic agent that binds competitively at lysine binding site on ...
Tamil Anbu Pannerselvam, Kodali V Rajesh kumar, Ranjith B Karthekeyan   +2 more
doaj   +1 more source

Safety and Efficacy of Local Tranexamic Acid for the Prevention of Surgical Bleeding in Soft-Tissue Surgery: A Review of the Literature and Recommendations for Plastic Surgery

Plastic and Reconstructive Surgery, 2022
Background: Although high-bleed surgery routinely utilizes the antifibrinolytic drug tranexamic acid, most plastic surgical procedures are conducted in soft tissue with low-volume bleeding.
Kjersti Ausen, R. Fossmark, O. Spigset, H. Pleym   +3 more
semanticscholar   +1 more source