Results 21 to 30 of about 5,067,781 (348)

Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression.

JAMA Surgery, 2021
Importance Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns remain about the potential adverse effects, particularly vascular occlusive events, that may be associated with its use.
Isabel Taeuber, S. Weibel, E. Herrmann, Vanessa Neef, T. Schlesinger, P. Kranke, Leila Messroghli, K. Zacharowski, S. Choorapoikayil, P. Meybohm   +9 more
semanticscholar   +1 more source

Update on Applications and Limitations of Perioperative Tranexamic Acid

Anesthesia and Analgesia, 2022
Tranexamic acid (TXA) is a potent antifibrinolytic with documented efficacy in reducing blood loss and allogeneic red blood cell transfusion in several clinical settings.
Prakash A. Patel, J. Wyrobek, A. Butwick, E. Pivalizza, G. Hare, C. Mazer, S. Goobie   +6 more
semanticscholar   +1 more source

Safety and Efficacy of Local Tranexamic Acid for the Prevention of Surgical Bleeding in Soft-Tissue Surgery: A Review of the Literature and Recommendations for Plastic Surgery

Plastic and Reconstructive Surgery, 2022
Background: Although high-bleed surgery routinely utilizes the antifibrinolytic drug tranexamic acid, most plastic surgical procedures are conducted in soft tissue with low-volume bleeding.
Kjersti Ausen, R. Fossmark, O. Spigset, H. Pleym   +3 more
semanticscholar   +1 more source

The effect of tranexamic acid in patients with TBI: a systematic review and meta-analysis of randomized controlled trials

Chinese Neurosurgical Journal, 2020
To conduct a systematic review and meta-analysis and evaluate the effect of tranexamic acid in patients with traumatic brain injury. PubMed, EMBASE, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched to identify randomized ...
Chao-nan Du, Bo-xue Liu, Qing-fang Ma, Ming-fei Yang   +3 more
doaj   +1 more source

Association of Tranexamic Acid Administration With Mortality and Thromboembolic Events in Patients With Traumatic Injury

JAMA Network Open, 2022
Key Points Question Is the administration of tranexamic acid associated with mortality and thromboembolic events in patients with traumatic injury? Findings This systematic review and meta-analysis included 31 randomized clinical trials and observational
V. Karl, S. Thorn, T. Mathes, S. Hess, M. Maegele   +4 more
semanticscholar   +1 more source

The effect of Tranexamic acid on cardiac surgery bleeding [PDF]

Reviews in Clinical Medicine, 2014
Serious bleeding in cardiac surgery leads to re-exploration, blood transfusion and increases the risks of mortality and morbidity. Using the lysine analogous of antifibrionlytic agents are the preferred strategy to suppress the need for transfusion ...
Mohammad Esmaeelzadeh, Shahram Amini
doaj   +3 more sources

Comparative Study of Two Different Intravenous Doses of Tranexamic Acid with Placebo on Surgical Field Quality in Functional Endoscopic Sinus Surgery-A Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Intraoperative haemorrhage, which disrupts surgical patency, is a major obstacle for surgeons, especially in endoscopic sinus surgeries. Tranexamic acid is synthetic antifibrinolytic agent that binds competitively at lysine binding site on ...
Tamil Anbu Pannerselvam, Kodali V Rajesh kumar, Ranjith B Karthekeyan   +2 more
doaj   +1 more source

Peritoneal dialysis catheter dysfunction due to fibrin clots following treatment with tranexamic acid: a clinical case

Bulletin de la Dialyse à Domicile, 2021
Chronic kidney disease patients experience not only more frequent arterial and venous thrombosis but also hemorrhagic episodes. Tranexamic acid is an anti-fibrinolytic molecule that inhibits plasmin activation.
Elodie Bogner, Elodie Ferrero, Joelle Marin, Stanislas Bataille   +3 more
doaj   +1 more source

Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis

Critical Care, 2021
Background Tranexamic acid (TXA) reduces surgical bleeding and reduces death from bleeding after trauma and childbirth. However, its effects on thrombotic events and seizures are less clear.
Shuhei Murao, Hidekazu Nakata, I. Roberts, K. Yamakawa   +3 more
semanticscholar   +1 more source

Can the prophylactic administration of tranexamic acid reduce the blood loss after robotic-assisted radical prostatectomy? Robotic Assisted Radical Prostatectomy with tranEXamic acid (RARPEX): study protocol for a randomized controlled trial

Trials, 2022
Background The prophylactic administration of tranexamic acid reduces blood loss during procedures at high risk of perioperative bleeding. Several studies in cardiac surgery and orthopedics confirmed this finding.
M. Balik, J. Kosina, P. Husek, J. Pacovsky, M. Brodak, F. Cecka   +5 more
doaj   +1 more source