Specificity of ARGONAUTE7-miR390 Interaction and Dual Functionality in TAS3 Trans-Acting siRNA Formation [PDF]
Cell, 2008 SummaryTrans-acting siRNA form through a refined RNAi mechanism in plants. miRNA-guided cleavage triggers entry of precursor transcripts into an RNA-DEPENDENT RNA POLYMERASE6 pathway, and sets the register for phased tasiRNA formation by DICER-LIKE4 ...
Taiowa A. Montgomery +9 more
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Cascading cis-cleavage on transcript from trans-acting siRNA-producing locus 3. [PDF]
Int J Mol Sci, 2013 The production of small RNAs (sRNAs) from phased positions set by microRNA-directed cleavage of trans-acting-siRNA-producing locus (TAS) transcript has been characterized extensively; however, the production of sRNAs from non-phased positions remains ...
Zhang C, Li G, Wang J, Zhu S, Li H.
europepmc +4 more sources
Small RNAs mediate transgenerational inheritance of genome-wide trans-acting epialleles in maize
Genome Biology, 2022 Background Hybridization and backcrossing are commonly used in animal and plant breeding to induce heritable variation including epigenetic changes such as paramutation.
Shuai Cao +8 more
doaj +3 more sources
Simple gene silencing using the trans-acting siRNA pathway. [PDF]
Plant Biotechnol J, 2016 In plants, particular micro-RNAs (miRNAs) induce the production of a class of small interfering RNAs (siRNA) called trans-acting siRNA (ta-siRNA) that lead to gene silencing.
Jacobs TB +4 more
europepmc +2 more sources
SDE5, the putative homologue of a human mRNA export factor, is required for transgene silencing and accumulation of trans‐acting endogenous siRNA [PDF]
The Plant Journal, 2007 Post-transcriptional gene silencing (PTGS) is a sequence-specific RNA degradation process conserved in fungi, plants and animals. The trigger of the mechanism is double-stranded RNA derived from transgenic or endogenous loci and formed by intra- or inter-
Inmaculada Hernández‐Pinzón +5 more
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Trans-acting siRNA-mediated repression of ETTIN and ARF4 regulates heteroblasty inArabidopsis
Development, 2006 Mutations in the ARGONAUTE gene ZIPPY(ZIP)/AGO7 in Arabidopsis accelerate the juvenile-to-adult transition. A screen for mutations that suppress this precocious phenotype yielded alleles of two auxin-related transcription factors known to be upregulated ...
Christine Hunter +5 more
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Predicted Trans-Acting siRNAs in the Human Brain [PDF]
International Journal of Molecular Sciences, 2015 Endogenous small non-coding RNAs play pivotal roles in regulating gene expression in eukaryotes. Many studies have investigated the function and molecular mechanism of microRNAs in the development and disease of various organisms via mRNA repression of ...
Xiaoshuang Liu +3 more
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Identification of trans-acting siRNAs and their regulatory cascades in grapevine [PDF]
Bioinform., 2012 MOTIVATION Trans-acting small interfering RNAs (ta-siRNAs) play an essential role in the regulation of plant gene expression, but relevant reports are still limited.
Changqing Zhang +3 more
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Genome-wide analysis of leafbladeless1-regulated and phased small RNAs underscores the importance of the TAS3 ta-siRNA pathway to maize development. [PDF]
PLoS Genetics, 2014 Maize leafbladeless1 (lbl1) encodes a key component in the trans-acting short-interfering RNA (ta-siRNA) biogenesis pathway. Correlated with a great diversity in ta-siRNAs and the targets they regulate, the phenotypes conditioned by mutants perturbing ...
Marcela C Dotto +5 more
doaj +2 more sources
Nucleic Acids Research, 2008 Several RNA silencing pathways in plants restrict viral infections and are suppressed by distinct viral proteins. Here we show that the endogenous trans-acting (ta)siRNA pathway, which depends on Dicer-like (DCL) 4 and RNA-dependent RNA polymerase (RDR ...
P. V. Shivaprasad +6 more
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