Results 101 to 110 of about 31,835 (252)

Expression and processing of polycistronic artificial microRNAs and trans -acting siRNAs in Solanum lycopersicum and Nicotiana benthamiana [PDF]

, 2021
Alice Lunardon, Samwel Muiruri, Michael J. Axtell   +2 more
openalex   +1 more source

Genotypes and Phenotypes of Patients With TSPEAR‐Related Disorder: Evidence of a Predominant Dental Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT TSPEAR (chr. 21q22.3) encodes a protein involved in tooth development and is predominantly expressed in the enamel knot. Biallelic loss of function variants in TSPEAR cause ectodermal dysplasia, tooth agenesis and sensorineural hearing loss. However, the role of TSPEAR in auditory processes is unclear.
Debora Vergani, Lucia Tiberi, Annarita Giliberti, Elia Dirupo, Laila Zaroili, Francesco Brancati, Michela Brena, Stefano Caraffi, Chiara De Luca, Livia Garavelli, Anna Virginia Gulino, Milena Mariani, Marzia Pollazzon, Angelo Selicorni, Samuela Landini, Ilaria Sani, Rosangela Artuso, Angela Peron   +17 more
wiley   +1 more source

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

Cytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook, Edna C. Hardeman, Peter W. Gunning   +2 more
wiley   +1 more source

Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
Macrophages stimulated by BCG significantly enhanced endothelial cell proliferation, migration, and tube formation. Mechanistically, this pro‐angiogenic activity was reliant on activating NF‐αB or other signaling pathways, which induced the upregulation of HIF‐1α and VEGFA.
Yuyang Hou, Yuxi Wang, Qiong Wu, Wenjing Du, Shanzhu Guo, Xinyu Chai, Yinan Wang, Huixin Liang, Hongyan Yuan, Jun Li, Dongmei Yan   +10 more
wiley   +1 more source

HMGB1 Assists in Overcoming Cisplatin Resistance in Chemoresistant Human Ovarian Cancer Cells

Molecular Carcinogenesis, EarlyView.
ABSTRACT Cisplatin is one of the most effective chemotherapeutic agents used in the treatment of ovarian cancer. However, the frequent development of cisplatin resistance remains a significant limitation, leading to therapeutic failure and poor patient outcomes.
Van Huynh, Guliang Wang, Anirban Mukherjee, Karen M. Vasquez   +3 more
wiley   +1 more source

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, EarlyView.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

Circular RNAs: Epigenetic Puppeteers Pulling the Strings of Cancer Pathogenesis

Medicine Bulletin, EarlyView.
ABSTRACT Circular RNAs (circRNAs), a unique class of endogenous noncoding RNAs characterized by their covalently closed loop structure, have emerged as pivotal players in cancer biology due to their exceptional stability, tissue‐specific expression, and diverse regulatory functions.
Yimao Wu, Zichang Chen, Junying Lee, Gokhan Zengin, Meng‐Yao Li   +4 more
wiley   +1 more source

The Roles of Plant MicroRNAs in Defence Against Pathogens. [PDF]

Mol Plant Pathol
miRNAs modulate plant immunity against various pathogens, including fungi, bacteria, viruses, nematodes and oomycetes, by targeting pathogen effectors and modulating hormonal signalling. ABSTRACT MicroRNAs (miRNAs) are a class of noncoding RNAs that play important roles in regulating gene expression.
Mahamadou AM, Abdoulaye AH, Chen Y, Zheng L, Masangano M, Bruno AK, Chen Y.   +6 more
europepmc   +2 more sources