Results 121 to 130 of about 46,086 (263)

Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p [PDF]

, 2015
microRNAs (miRNAs) are abundantly expressed in development where they are critical determinants of cell differentiation and phenotype. Accordingly miRNAs are essential for normal skeletal development and chondrogenesis in particular.
Akiyama, Albers, Baek, Baraniskin, Bartel, Barter, Berschneider, Bhushan, Bi, Boland, Chiang, Chun, DeLise, Djebali, Dongen, Eberhart, Ebert, Feigin, Friedman, Fu, Furumatsu, Golan, Gradus, Grumolato, Hwang, Jenkins, Kai, Kanamori, Karlsen, Karlsson, Kolben, Korinek, Krol, Laine, Lalevee, Li, Li, Liu, Liu, Lyons, Miyaki, Miyaki, Murdoch, Nakamura, Onyekwelu, Pais, Parikh, Pittenger, Radwan, Roelofs, Rui, Schulz, Smyth, Song, Sorrentino, Staines, Sumiyoshi, Swingler, Tardif, Taylor, Tuddenham, Vonk, Wang, Wang, Xu, Yamashita, Yang, Yang, Yano, Yuan, Zeybel, Zhang, Zhang   +72 more
core   +1 more source

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

Advanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang, Chengming Gao, Haibei Li, Yuying Chen, Liting Yang, Qian Jin, Lan Feng, Xia Wang, Xinyi Liu, Hongxia Chen, Rong Ye, Yuanchao Xue, Huiyun Wang, Musheng Zeng, Ming Yang, Huaiqiang Ju, Chengzhi Gao, Guangming Zhou, Qi Zhang, Qian Zhang, Geng Qin, Yuanfeng Li, Yahui Wang, Aiqing Yang, Anfeng Si, Qingfeng Song, Fuchu He, Pengbo Cao, Gangqiao Zhou   +28 more
wiley   +1 more source

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin‐mediated Phagocytic Effects for Lung Cancer Treatment

Advanced Science, EarlyView.
Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye, Wei‐Bang Yu, Mu‐Yang Huang, Yan‐Yan Chen, Le‐Le Zhang, Chung‐Hang Leung, Xiao‐Lei Zhang, Zhenghai Tang, Ting Li, Jin‐Jian Lu   +9 more
wiley   +1 more source

FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates [PDF]

, 2019
The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
Abert, Christine, Bock-Bierbaum, Tobias, Danieli, Alberto, Daumke, Oliver, Shi, Xiaoshan [u.v.m.], Su, Ming-Yuan, Sztacho, Martin, Trapannone, Riccardo, Turco, Eleonora, Witt, Marie   +9 more
core   +1 more source

Procyanidin B3 and Its Derivatives Alleviate Neuronal Injury by Targeting G3BP1 for Ischemic Stroke Therapy

Advanced Science, EarlyView.
Ischemic stroke is a serious disease with high rates of mortality and disability, but there is a lack of novel therapeutic targets and agents for it. Now it is shown that Ras GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) has the potential to serve as a therapeutic target for ischemic stroke.
Heyanhao Zhang, Yuyu Zhang, Yibo Chen, Wen Zhong, Subei Tan, Jinghuan Wang, Huanren Yan, Ning Yan, Mengjia Lin, Xinhua Liu, Jun Chang   +10 more
wiley   +1 more source

Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1

Advanced Science, EarlyView.
This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu, Guigen Zhang, Yuan Lin, Shiming Yi, Jingyu Yang, Xueying Lin, Deli Song, Zhiheng Liu, Jiayu Zhang, Ying Zeng, Shanyu Huang, Zhen Fan, Jifu Zhang, Ying Liu, Cheng Hu, Wenbo Zhu, Wei Yin, Jun Hu, Guangmei Yan, Jing Cai, Jiankai Liang   +20 more
wiley   +1 more source

Plant responses to photoperiod [PDF]

, 2009
Photoperiod controls many developmental responses in animals, plants and even fungi. The response to photoperiod has evolved because daylength is a reliable indicator of the time of year, enabling developmental events to be scheduled to coincide with ...
Abe, Achard, Adams, Adams, Alabadi, An, Asai, Aukerman, Balasubramanian, Banerjee, Batutis, Beales, Ben-Naim, Berardini, Bernier, Blazquez, Blázquez, Blázquez, Bollman, Bongard-Pierce, Borchert, Bouveret, Bäurle, Böhlenius, Cerdán, Chae, Chailkhyan, Chen, Chen, Chien, Chincinska, Clarke, Cockcroft, Corbesier, David, Devlin, Doi, Dudley, Duncan, Fahlgren, Farré, Foster, Fowler, Gandikota, Gardner, Giavalisco, Goldman, Gonthier, Grigg, Hackett, Halliday, Hayama, Hayama, Haywood, He, He, Henderson, Heyer, Holm, Hotta, Hsu, Hunter, Hunter, Imaizumi, Imaizumi, Izawa, Jackson, Jackson, Jackson, Jackson, Jaeger, Jang, Jung, Kanrar, Kelly, Kim, Kim, Kim, Kim, Kojima, Komiya, Kotake, Kusnetsov, Laubinger, Lauter, Lee, Lee, Lin, Martinez-Garcia, Martínez, Mathieu, McClung, Michael, Moon, Mouradov, Más, Nilsson, Onouchi, Orkwiszewski, Osterlund, Park, Peragine, Pineiro, Poethig, Poethig, Pouteau, Razem, Reeves, Roberts, Robinson, Robson, Roden, Rodriguez-Falcon, Saijo, Samach, Sawa, Schmid, Schwarz, Searle, Seo, Singer, Sivitz, Smith, Somers, Souer, Stadler, Steward, Suàrez-López, Swiezewski, Takada, Takeno, Tamaki, Telfer, Tessadori, Thomas, Turner, Valverde, Vega, Von Arnim, Wang, Wang, Weigel, Wenkel, Wigge, Willmann, Wu, Xie, Yamaguchi, Yan, Yanovsky, Yanovsky, Yoo, Yoo, Yu, Zeevaart   +154 more
core   +1 more source

Strategic Timing of Gene Silencing: Cellular Kinetics‐Based Administration of siRNA for Optimized Photothermal Cancer Treatment

Advanced Science, EarlyView.
Coordinating therapy with gene expression kinetics emerges as a key strategy for maximizing nanomedicine efficacy in aggressive cancers. A hybrid nanocarrier delivering HSP70‐targeting siRNA demonstrates this chronotherapeutic principle through systematic cellular profiling.
Tianliang Fang, Li Li, Ziyad Tariq Muhseen, Lucas A. Lane, Huiming Cai, Christopher J. Butch, Yiqing Wang   +6 more
wiley   +1 more source

Partial Reprogramming in Senescent Schwann Cells Enhances Peripheral Nerve Regeneration via Restoration of Stress Granule Homeostasis

Advanced Science, EarlyView.
In this study, it is discovered that pathological accumulation of Runx2+ Schwann cell clusters​ during axonal regeneration is a key factor impairing nerve repair in aging. This pathology is associated with ​dysregulation of stress granule homeostasis.
Peilin Wang, Renyuan Wang, Yilin Huo, Ying Peng, Chuanliang Fu, Yi Hu, Zun Ren, Yersen Mulat, Hao Zhang, Dongsheng Jiang, Haodong Lin   +10 more
wiley   +1 more source

Nucleic Acid‐Based Molecular Machines for Biological Applications

Advanced NanoBiomed Research, EarlyView.
Molecular machines are devices assembled from molecules with specific functions. In this review, the development of DNA nanostructures, which are then assembled into molecular machines, is summarized. Their classification and biological applications, such as biosensing, targeted therapy, and molecular circuits are introduced.
Yirong Guo, Xiaolei Zuo, Fangfei Yin
wiley   +1 more source