Results 131 to 140 of about 30,445 (234)

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington's Disease. [PDF]

Pharmaceutics
Morales LC, Modi L, Abbasi Dezfouli S, Rajendran AP, Kc R, Kadam V, Sipione S, Uludağ H.   +7 more
europepmc   +1 more source

Gaining insights into epigenetic memories through artificial intelligence and omics science in plants

Journal of Integrative Plant Biology, EarlyView.
This review explores how artificial intelligence and machine learning predict plant behavior in response to environmental stress by modeling molecular regulatory networks of plant stress responses. Their combined application with omics methods opens new avenues in understanding the functioning of plant memory and future plant memory‐based plant ...
Judit Dobránszki, Valya Vassileva, Dolores R. Agius, Panagiotis Nikolaou Moschou, Philippe Gallusci, Margot M.J. Berger, Dóra Farkas, Marcos Fernando Basso, Federico Martinelli   +8 more
wiley   +1 more source

Empowering plant epigenetics to breed resilience of crops: From nucleolar dominance to transgenerational epigenetic inheritance. [PDF]

Plant Genome
Chen ZJ.
europepmc   +1 more source

RNA elements and their biotechnological applications in plants

New Phytologist, EarlyView.
Summary Engineering of plants for improved traits and efficient heterologous protein production can be achieved by modifying or introducing cis‐ or trans‐acting RNA elements. The function of these elements depends not only on their nucleotide sequence but also on their highly dynamic higher order structures.
Filip Lastovka, Hadrien Peyret, George P. Lomonossoff, Betty Y.‐W. Chung   +3 more
wiley   +1 more source

RNA interference and turnover in plants -a complex partnership. [PDF]

Front Plant Sci
Krzyszton M, Kufel J, Zakrzewska-Placzek M.   +2 more
europepmc   +1 more source

miR825‐5p‐regulated TNLs govern Arabidopsis resistance to Tetranychus urticae and Pieris brassicae

New Phytologist, EarlyView.
Summary MicroRNAs are essential regulators in plant resistance to biotic stresses, but their specific roles in the plant–herbivore context require deeper investigation. Here, we studied how the Arabidopsis miR825‐5p differentially modulates certain TNLs (MRT1, MRT2, and MIST1), triggering defensive responses against the sucking acari Tetranychus ...
Irene Rosa‐Diaz, Diego Lopez‐Marquez, Carmen R. Beuzon, Isabel Diaz   +3 more
wiley   +1 more source

Recovery of RNA-dependent RNA polymerase 6 gene-knockout phenotypes in Nicotiana benthamiana via in vivo generation of inverted repeat construct of the trans-acting short interference RNA3 sequence. [PDF]

Plant J
Matsuo K.
europepmc   +1 more source

An integrative multi‐omics analysis of histone modifications and DNA methylation reveals the epigenomic landscape in apple under drought stress

Plant Biotechnology Journal, EarlyView.
Summary Epigenetic regulation plays a key role in plant development and stress response processes. Although previous studies have found that epigenetic modifications are involved in the drought response in apple, a comprehensive epigenomic profile of the response of apple to drought is needed.
Shicong Wang, Jieqiang He, Bichun Hu, Mengting Deng, Wenjie Li, Junxing Guo, Yi Song, Qianming Zheng, Xiaolin Song, Fengwang Ma, Jiangbo Wang, Qingmei Guan, Jidi Xu   +12 more
wiley   +1 more source

Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers. [PDF]

Nat Commun
Oo JA, Warwick T, Pálfi K, Lam F, McNicoll F, Prieto-Garcia C, Günther S, Cao C, Zhou Y, Gavrilov AA, Razin SV, Cabrera-Orefice A, Wittig I, Pullamsetti SS, Kurian L, Gilsbach R, Schulz MH, Dikic I, Müller-McNicoll M, Brandes RP, Leisegang MS.   +20 more
europepmc   +1 more source