Results 161 to 170 of about 31,835 (252)

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
wiley   +1 more source

The REDUCED LEAFLET Genes Encode Key Components of the trans-Acting Small Interfering RNA Pathway and Regulate Compound Leaf and Flower Development in Lotus japonicus1[W][OA]

Plant Physiology, 2009
Jun Yan, X. Cai, Jiang-hong Luo, Shusei Sato, Qunyi Jiang, Jun Yang, Xiangling Cao, Xiao-he Hu, S. Tabata, P. Gresshoff, D. Luo   +10 more
semanticscholar   +1 more source

Empowering plant epigenetics to breed resilience of crops: From nucleolar dominance to transgenerational epigenetic inheritance. [PDF]

Plant Genome
Chen ZJ.
europepmc   +1 more source

Hibiscus chlorotic ringspot virus coat protein inhibits trans-acting small interfering RNA biogenesis in Arabidopsis.

Journal of General Virology, 2008
Chunying Meng, Jun Chen, S. Ding, Jinrong Peng, Sek-Man Wong   +4 more
semanticscholar   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, Volume 13, Issue 2, 9 January 2026.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers. [PDF]

Nat Commun
Oo JA, Warwick T, Pálfi K, Lam F, McNicoll F, Prieto-Garcia C, Günther S, Cao C, Zhou Y, Gavrilov AA, Razin SV, Cabrera-Orefice A, Wittig I, Pullamsetti SS, Kurian L, Gilsbach R, Schulz MH, Dikic I, Müller-McNicoll M, Brandes RP, Leisegang MS.   +20 more
europepmc   +1 more source

Overcoming EGFR‐Mediated Dendritic Cell Dysfunction to Enhance Anti‐tumor Immunity in EGFR‐Mutant NSCLC by Precisely Targeting CD73 With pH‐responsive Nanocarriers

Advanced Science, Volume 13, Issue 1, 5 January 2026.
EGFR mutations drive ERK/c‐Jun–mediated transcriptional activation of CD73, elevating adenosine levels and fostering an immunosuppressive TME by impairing DC maturation and CD8⁺ T cell priming. The pH‐responsive nanodrug F127ZIF‐8AB680 selectively inhibits CD73, normalizes adenosine metabolism, and re‐establishes effective anti‐tumor immunity ...
Xiaoling Shang, Xudong Geng, Zixu Wang, Shumin Yuan, Shanshan Ding, Ni Liu, Xinchun Ma, Xuan Sun, Huimin Wang, Ying Sun, Xun Qu, Guangwen Ren, Yong Qiang Li, Xiuwen Wang, Yanguo Liu   +14 more
wiley   +1 more source

Antiviral RNA interference in plants: Increasing complexity and integration with other biological processes. [PDF]

Plant Commun
Li F, Li X, Zhao S, Pan F, Li Z, Hao Y, He J, Wang A, Kormelink R, Zhou X.   +9 more
europepmc   +1 more source

Fabp5 Is the Key Regulator Mediating γ‐CEHC Differentiation in Osteoblasts and Osteoclasts

BioFactors, Volume 52, Issue 1, January/February 2026.
γ‐CEHC, as a natural Fabp5 inhibitor, ameliorates the osteoporotic microenvironment through a triple‐action mechanism—targeting Fabp5 inhibition → modulating macrophage polarization → balancing bone metabolism—highlighting its translational medical value.
Cheng Cheng, Rong Chen, Minjuan Li, Shuai Lu, Xinping Li, Gengli Cui, Hailing Chen, Xieyuan Jiang   +7 more
wiley   +1 more source

RNA interference and turnover in plants -a complex partnership. [PDF]

Front Plant Sci
Krzyszton M, Kufel J, Zakrzewska-Placzek M.   +2 more
europepmc   +1 more source