Results 181 to 190 of about 30,445 (234)

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, Volume 58, Issue 8, August 2025.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Dosage-sensitive maternal siRNAs determine hybridization success in Capsella. [PDF]

Nat Plants
Dziasek K, Santos-González J, Wang K, Qiu Y, Zhu J, Rigola D, Nijbroek K, Köhler C.   +7 more
europepmc   +1 more source

Repurposing Asparaginase Therapy to Target Cisplatin‐Resistant Cancer Cells

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT Background Cisplatin and its derivatives remain a cornerstone in the treatment of solid malignancies. Resistance is a major factor limiting their clinical utility. Objectives In the present study, we set out to interrogate therapeutic approaches to target cisplatin‐resistant cancer cells.
Jiantao Wang, Nasim Pouryaghoub, Robert Strauss, Jiri Bartek, Si Min Zhang, Sean G. Rudd   +5 more
wiley   +1 more source

Non-canonical Function of Prolyl Hydroxylase Domain 2 in Breast Cancer Cell Growth and Progression: Role of Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1. [PDF]

J Cancer Prev
Guillen-Quispe YN, Kim SJ, Saeidi S, Choi GJ, Chelakkot C, Zhou T, Bang SB, Kim TW, Shin YK, Surh YJ.   +9 more
europepmc   +1 more source

ZNF224 enhances the oncogenic function of p21 via p53 and AKT pathways in melanoma

The FEBS Journal, Volume 292, Issue 15, Page 3986-4005, August 2025.
KRAB zinc finger protein ZNF224 acts as an oncogenic factor in melanoma cells, enhancing p21 cytosolic retention and impairing nuclear p21 cytostatic activity through stimulation of the AKT pathway. Furthermore, ZNF224 regulates transcriptional expression levels of p21 via p53.
Leandra Sepe, Umberto Candia, Dario Sasso del Verme, Elvira Toscano, Marianna Toriello, Gaetano Sodaro, Roberta Rapuano, Simona Romano, Michela Grosso, Giovanni Paolella, Angelo Lupo, Paola Costanzo, Elena Cesaro   +12 more
wiley   +1 more source

Annexin A1 Is Involved in the Antitumor Effects of 5-Azacytidine in Human Oral Squamous Carcinoma Cells. [PDF]

Cancers (Basel)
Novizio N, Belvedere R, Palazzo M, Varricchio S, Merolla F, Staibano S, Ilardi G, Petrella A.   +7 more
europepmc   +1 more source

Hybridization and gene expression: Beyond differentially expressed genes

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract Gene expression has a key role in reproductive isolation, and studies of hybrid gene expression have identified mechanisms causing hybrid sterility. Here, we review the evidence for altered gene expression following hybridization and outline the mechanisms shown to contribute to altered gene expression in hybrids. Transgressive gene expression,
Anna Runemark, Emily C. Moore, Erica L. Larson   +2 more
wiley   +1 more source

Cloning and Transcriptional Activity Analysis of the Bovine <i>CDH11</i> Gene Promoter: Transcription Factors Sp1 and GR Regulate Bovine <i>CDH11</i> Expression. [PDF]

Animals (Basel)
Liu Z, Bai Y, Chen Z, Niu Y, Jia X, Li L, Zhang X, Shi B, Zhao Z, Hu J, Luo Y, Wang J, Liu X, Li S, Zhao F.   +14 more
europepmc   +1 more source

Non‐coding RNAs in plant stress responses: molecular insights and agricultural applications

Plant Biotechnology Journal, Volume 23, Issue 8, Page 3195-3233, August 2025.
Summary Non‐coding RNAs (ncRNAs) have emerged as crucial regulators in plant responses to environmental stress, orchestrating complex networks that finetune gene expression under both abiotic and biotic challenges. To elucidate this intricate ncRNA crosstalk, this review comprehensively summarizes recent advances in understanding the mechanisms of key ...
Xiaotong Chen, Zhaohui Chen, Ryan Watts, Hong Luo   +3 more
wiley   +1 more source

Discovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer's disease. [PDF]

Sci Rep
Campagna J, Chandra S, Teter B, Cohn W, Pham J, Kim YS, Jagodzinska B, Vadivel K, Alam P, Bilousova T, Young M, Elias C, Marcucci J, Flacau I, Jackman A, Padder S, Wi D, Zhu C, Spilman P, Jung ME, Bredesen DE, John V.   +21 more
europepmc   +1 more source