Results 181 to 190 of about 59,578 (250)

New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song, Adrian H. Bustos, Lise Bastue, Justas Mikutavicius, Piotr Swiderski, Kelly J. Clemens, Nagy Habib, John Rossi, Kira Astakhova   +8 more
wiley   +2 more sources

Advances in Small RNA Regulation of Female Gametophyte Development in Flowering Plants. [PDF]

Plants (Basel)
Liu Y, He Q, Su H, Xi X, Xu X, Qin Y, Cai H.   +6 more
europepmc   +1 more source

High‐throughput screening identifies bazedoxifene as a potential therapeutic for dysferlin‐deficient limb girdle muscular dystrophy

British Journal of Pharmacology, Volume 182, Issue 13, Page 2930-2949, July 2025.
Abstract Background and Purpose Limb‐girdle muscular dystrophy R2 (LGMD R2) is a rare genetic disorder characterised by progressive weakness and wasting of proximal muscles. LGMD R2 is caused by the loss of function of dysferlin, a transmembrane protein crucial for plasma membrane repair in skeletal muscles.
Celine Bruge, Nathalie Bourg, Emilie Pellier, Johana Tournois, Jerome Polentes, Manon Benabides, Noella Grossi, Anne Bigot, Anthony Brureau, Isabelle Richard, Xavier Nissan   +10 more
wiley   +1 more source

Amelioration of Liver Fibrosis via In Situ Hepatic Stellate Cell Conversion Through Co‐Inhibition of TGF‐β and GSK‐3 Signalling

Liver International, Volume 45, Issue 7, July 2025.
ABSTRACT Background and Aims Liver fibrosis, a progressive condition driven by chronic liver injury and excessive scar tissue formation, can lead to cirrhosis, a life‐threatening disease. Activation of hepatic stellate cells (HSCs) is central to fibrosis progression, yet current therapies fail to halt or reverse this process.
Xiang‐Jie Zhu, Zhi Zhong, Jiang‐Chuan Du, Jiu‐Yu Zhang, Xu Zhang, Xiu‐Liang Cui, Ling‐Ting Guan, Yan‐Yu Hu, Can Chen, Han Wang, Xiang‐Yu Wu, Wei‐Jia Zhang, Pei‐Lin Zhang, Hong‐Yang Wang   +13 more
wiley   +1 more source

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects [PDF]

, 2017
Diamond, Michael S, et al,, Govero, Jennifer   +2 more
core   +2 more sources

Aberrant Splicing as a Mechanism for Resistance to Cancer Therapies. [PDF]

Cancers (Basel)
Duzgun D, Oltean S.
europepmc   +1 more source

Small Interfering RNAs as Critical Regulators of Plant Life Process: New Perspectives on Regulating the Transcriptomic Machinery. [PDF]

Int J Mol Sci
Puchta-Jasińska M, Bolc P, Pietrusińska-Radzio A, Motor A, Boczkowska M.   +4 more
europepmc   +1 more source

Failure of the Tomato Trans-Acting Short Interfering RNA Program to Regulate AUXIN RESPONSE FACTOR3 and ARF4 Underlies the Wiry Leaf Syndrome[C][W]

The Plant Cell, 2012
Tamar Yifhar, I. Pekker, D. Peled, G. Friedlander, Anna Pistunov, Moti Sabban, Guy Wachsman, J. Alvarez, Z. Amsellem, Y. Eshed   +9 more
semanticscholar   +1 more source

SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing. [PDF]

Elife
Govindan A, Conrad NK.
europepmc   +1 more source

CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer. [PDF]

Cell Rep
Xiang RR, Lee SA, Tyndall CF, Bhatia AR, Yin J, Singler C, Hauk BJ, Kipp MP, Takeda DY.   +8 more
europepmc   +1 more source