Results 191 to 200 of about 31,835 (252)

Functionalizing Nucleic Acids: Synthesis and Purification Strategies for Bioconjugates as Biomaterials

Small, Volume 22, Issue 5, 22 January 2026.
Nucleic acid‐ligand conjugates combine the distinct properties of macromolecular ligands with the versatility of DNA/RNA nanotechnology. In biomaterial and nanomedicine applications, highly purified products are paramount, requiring reliable synthesis and purification methods.
Nico Alleva, Jian Zhang, David Y. W. Ng, Tanja Weil, Torsten John   +4 more
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, Volume 10, Issue 2, 22 January 2026.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Small RNA, big defence: Early epigenetic responses to genetic invasion. [PDF]

Quant Plant Biol
Mun S, Kang YJ, Cho J.
europepmc   +1 more source

PBX1 Improves Cognition and Reduces Amyloid‐β Pathology in APP/PS1 Mice by Transcriptionally Activating the CRTC2–CREB Pathway

Aging Cell, Volume 25, Issue 1, January 2026.
We found that the transcription factor PBX1 is markedly downregulated in patients with Alzheimer's disease and in disease models. Restoring PBX1 reduces Aβ pathology and rescues cognitive deficits. Mechanistically, PBX1 directly activates the transcription of CRTC2 and enhances p‐CREB signaling, thereby conferring neuroprotection.
Zinan Liu, Xiangyuan Meng, Rifeng Lu, Xiaoting Meng, Siyao Li, Yujie Wang, Xinpeng Liu, Xiaomei Liu, Jinyu Liu   +8 more
wiley   +1 more source

RNA G-quadruplexes promote codon repeat-associated ribosomal frameshifting in human genes. [PDF]

Nucleic Acids Res
Li X, Li Z, Zhou Y, Gong S, Chen Z, Li J, Guo M, Gu X, Li F, Wei J, Zhong T, Yin T, Li T, Xing Y, Yang X, Xu L, Lai F, Dang Y, Ren G.   +18 more
europepmc   +1 more source

miR‐375‐3p/STX6 Exacerbates Atherosclerosis by Promoting Endothelial Cell Senescence via Activation of TGF‐Beta Signals

Aging Cell, Volume 25, Issue 1, January 2026.
miR‐375‐3p promotes endothelial senescence by targeting STX6 and activating the SMAD2/p15 pathway (penal A). Inhibition of miR‐375‐3p or restoration of STX6 alleviates endothelial senescence and reduces atherosclerotic plaque formation in ApoE−/− mice (penal B).
Ying Zhu, Zhirui Liu, Yiqi Wan, Shuangjin Ding, Jiankun Liu, Andong Wu, Ximo Dai, Jin Zhou, Xueer Li, Xueting Gong, Man Liu, Xiao‐Li Tian   +11 more
wiley   +1 more source

Molecular Mechanisms of Plant Stress Memory: Roles of Non-Coding RNAs and Alternative Splicing. [PDF]

Plants (Basel)
Sintaha M.
europepmc   +1 more source

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age‐Related Diabetes in Mice

Aging Cell, Volume 25, Issue 1, January 2026.
hAMSC‐sEVs rejuvenate β cells and improve glycaemic control via the miR‐21‐5p/IL‐6RA/STAT3/MCU axis, restoring mitochondrial Ca2+ homeostasis and insulin secretion in aged T2DM mice. ABSTRACT Targeting senescent pancreatic β‐cells represents a promising therapeutic avenue for age‐related diabetes; however, current anti‐senescence strategies often ...
Lei Xiao, Zicheng Zhang, Tong Li, Yuyin Jiang, Yuanxin Liu, Tingting Lv, Lianju Qin, Yunxia Zhu, Wei Tang   +8 more
wiley   +1 more source

RAB5C Increases Endothelial Release of VWF by Regulating Vesicle Trafficking. [PDF]

Arterioscler Thromb Vasc Biol
Reventun P, Toledano-Sanz P, Delgado-Marin M, Viskadourou M, Foster DB, de Vries PS, Sabater-Lleal M, Alcharani N, Gonzalez-Cucharero C, Osburn WO, Morrison AC, Wolberg AS, Smith NL, Arvanitis M, Cohorts for Heart and Aging in Genomic Epidemiology Hemostasis Working Group, Lowenstein CJ.   +15 more
europepmc   +1 more source

lncDILC Downregulation in Liver Cancer‐Associated Fibroblasts Drives Pro‐Invasive Conversion via a miR‐6071‐ZNF395 Axis

Cancer Science, Volume 117, Issue 1, Page 145-155, January 2026.
We found in the present study the loss‐of‐function of a sequential inhibitory cascade of lncDILC‐miR‐6071‐ZNF395 in liver CAFs, which promoted the NF‐CAF conversion through increasing expression of pro‐invasive cytokines like IL‐6, LIF, CXCL12, and TGF‐β.
Yawen Li, Jilong Liu, Shentao Tai, Dandan Tong, Bifeng Wang, Dingbing Lu, Guoqing Shi, Xuemei Liu   +7 more
wiley   +1 more source