Results 201 to 210 of about 46,086 (263)

Blocking YAP1-Liprin-β2 interaction impedes metastasis and promotes tumor suppression in head and neck squamous carcinoma. [PDF]

Sci Rep
Woo SR, Noh JK, Lee MK, Kong M, Min S, Sung JY, Na K, Kang S, Hur JK, Ko SG, Eun YG.   +10 more
europepmc   +1 more source

GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density. [PDF]

Genome Biol
Conery M, Pippin JA, Wagley Y, Trang K, Pahl MC, Villani DA, Favazzo LJ, Ackert-Bicknell CL, Zuscik MJ, Katsevich E, Wells AD, Zemel BS, Voight BF, Hankenson KD, Chesi A, Grant SFA.   +15 more
europepmc   +1 more source

De novo assembly of RNA m⁶A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation. [PDF]

Cell Rep
Grande RC, Lin CC, Cammer M, Emesom ED, Khurram MA, Boutell C, Denes LT, Lionnet T, Wilson AC, Mohr I.   +9 more
europepmc   +1 more source

Calumenin, A Calcium‐Binding Modulatory Protein, Effective in Pathological Calcifications and Cancers, With Therapeutic Application Promise

FASEB BioAdvances, Volume 7, Issue 10, October 2025.
Calumenin (CALU) is effective in calcium homeostasis, involved in various cellular processes, ER‐related functions, normal calcification processes, pathological calcium deposits, inflammatory diseases, and cancers. Additionally, it has been linked to cancer by controlling the γ‐carboxylation of vitamin K‐dependent proteins linked to cancer.
Parinaz Nasri Nasrabadi, Babak Jahangiri, Zahra Amiri, Forouzandeh Mahjoubi, Fatemeh Masoumi, Alireza Zomorodipour   +5 more
wiley   +1 more source

MIAT promotes tumor-infiltrating CD8⁺ T-cell exhaustion and malignant progression of renal cell carcinoma via activating JAK3/STAT3 pathway. [PDF]

J Immunother Cancer
Zhang MX, Jing LY, Tan HT, Dai ZR, Long DZ, Liu HC, Yu AZ, Wang B, Chen ZY, Luo JH, Chen ZH, Wang JF.   +11 more
europepmc   +1 more source

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, Volume 182, Issue 20, Page 4741-4760, October 2025.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source

Role of long non-coding RNAs in cartilage development and osteoarthritis pathogenesis. [PDF]

Eur J Med Res
Sun X, Wang S, Tian J, Li M.
europepmc   +1 more source

Repurposing Asparaginase Therapy to Target Cisplatin‐Resistant Cancer Cells

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT Background Cisplatin and its derivatives remain a cornerstone in the treatment of solid malignancies. Resistance is a major factor limiting their clinical utility. Objectives In the present study, we set out to interrogate therapeutic approaches to target cisplatin‐resistant cancer cells.
Jiantao Wang, Nasim Pouryaghoub, Robert Strauss, Jiri Bartek, Si Min Zhang, Sean G. Rudd   +5 more
wiley   +1 more source

siRNA Therapeutics for the Treatment of Hereditary Diseases and Other Conditions: A Review. [PDF]

Int J Mol Sci
Shevelev A, Pozdniakova N, Generalov E, Tarasova O.   +3 more
europepmc   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, Volume 292, Issue 20, Page 5288-5323, October 2025.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source