Results 201 to 210 of about 31,835 (252)

The non-synthetic sweeteners, miraculin and mogroside V, but not stevia, disrupt the intestinal epithelial barrier function through a sweet taste receptor-dependent mechanism. [PDF]

Sci Rep
Shil A, Amoakohene O, Chichger H.
europepmc   +1 more source

Staufen dsRNA-binding domain as modules to design bifunctional antibodies for siRNA delivery. [PDF]

Nucleic Acids Res
Liu Y, Zheng Y, Xu R, Quan Y, Tai W.
europepmc   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Uncovering cargo clients and accessory factors of AP-1 and AP-4 through vesicle proteomics. [PDF]

Proc Natl Acad Sci U S A
Peng Z, Fan J, Liu Y, Jia Q, An J, Wang J, Huang Y, Yao ZP, Guo Y.   +8 more
europepmc   +1 more source

Enhanced microRNA accumulation and gene silencing efficiency through optimized precursor base pairing

The Plant Journal, Volume 125, Issue 1, January 2026.
Significance Statement A large‐scale mutational analysis revealed that introducing a single G–C base pair upstream of the first DCL1 cleavage site in shc precursors enhances artificial microRNA accumulation and silencing efficiency, providing an optimized amiRNA precursor for improved gene regulation and biotechnological applications.
Juan‐José Llorens‐Gámez, Pedro José García‐Cano, Sara Rico‐Rodrigo, Lucía Duyos‐Casanova, Sara Toledano‐Franco, Alberto Carbonell   +5 more
wiley   +1 more source

Focal adhesion assembly and cell migration require myoferlin in PDAC cell lines. [PDF]

Sci Rep
Gullo C, Laverdeur E, Dancre M, Peiffer R, Boumahd Y, Agirman F, Malouhjamoum N, Désiront L, Thiry M, Rademaker G, Bellahcène A, Peulen O.   +11 more
europepmc   +1 more source

Immune System and Hepatic Stellate Cells’ Crosstalk in Liver Fibrosis: Pathways and Therapeutic Potential

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Liver fibrosis, characterized by the excessive deposition of extracellular matrix (ECM) driven by hepatic stellate cells (HSCs) activation, remains a critical challenge due to its progression to cirrhosis and hepatocellular carcinoma (HCC). This review clarifies the complex crosstalk between the immune system and HSCs, highlighting key cellular players
Wahyu Widowati, Adilah Hafizha Nur Sabrina, Annisa Firdaus Sutendi, Fadhilah Haifa Zahiroh, Aris Muhamad Nurjamil, Teresa Liliana Wargasetia, Ita Margaretha Nainggolan, Rizal Azis, Elham Rismani, Massoud Vosough, Poorani Gurumallesh Prabu   +10 more
wiley   +1 more source

Foliar-applied double-stranded RNA is mobile, transfers to plant pathogens, and triggers RNAi. [PDF]

Nucleic Acids Res
Brosnan CA, Fletcher SJ, Sawyer A, de Felippes FF, Carroll BJ, Waterhouse PM, Mitter N, Gardiner DM.   +7 more
europepmc   +1 more source

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Isolation and long‐term culture of primary mouse cholangiocytes that retain biophysical properties and distinct Cl‐conductances: An initial study

Physiological Reports, Volume 14, Issue 2, January 2026.
Mouse cholangiocytes are isolated from bile ducts and cultured in conditioned medium containing ROCK inhibitor. Cells maintain expression of biliary markers & ion channel activity for >50 passages. Abstract Cultures of primary mouse bile duct epithelial cells are a valuable tool to study cholangiocyte secretion and bile formation.
Qin Li, Youxue Wang, Kristy Boggs, Charles Kresge, Kari Nejak‐Bowen   +4 more
wiley   +1 more source