Results 51 to 60 of about 30,445 (234)

Unique expression, processing regulation, and regulatory network of peach (Prunus persica) miRNAs

BMC Plant Biology, 2012
Background MicroRNAs (miRNAs) have recently emerged as important gene regulators in plants. MiRNAs and their targets have been extensively studied in Arabidopsis and rice. However, relatively little is known about the characterization of miRNAs and their
Zhu Hong, Xia Rui, Zhao Bingyu, An Yong-qiang, Dardick Chris D, Callahan Ann M, Liu Zongrang   +6 more
doaj   +1 more source

Mycobacterial and HIV infections up-regulated human zinc finger protein 134, a novel positive regulator of HIV-1 LTR activity and viral propagation. [PDF]

PLoS ONE, 2014
BACKGROUND: Concurrent occurrence of HIV and Tuberculosis (TB) infections influence the cellular environment of the host for synergistic existence.
Ronald Benjamin, Atoshi Banerjee, Kannan Balakrishnan, Ramya Sivangala, Sumanlatha Gaddam, Sharmistha Banerjee   +5 more
doaj   +1 more source

STAT3‐mediated MLST8 gene expression regulates cap‐dependent translation in cancer cells

Molecular Oncology, 2020
Signal transducer and activator of transcription 3 (STAT3) regulates cell growth, cell survival, angiogenesis, metastasis of cancer cells, and cancer immune evasion by regulating gene expression as a transcription factor.
Hyunji Lee, Hyunjung Chin, Hyeyoung Kim, Hosung Jung, Daekee Lee   +4 more
doaj   +1 more source

MIGS as a Simple and Efficient Method for Gene Silencing in Rice

Frontiers in Plant Science, 2018
MiRNA-induced gene silencing (MIGS) technology is a special kind of RNA interference technology that uses miR173 to mediate the production of trans-acting siRNA (ta-siRNA) to achieve target gene silencing.
Xuelian Zheng, Lijia Yang, Qian Li, Linyi Ji, Aiting Tang, Lili Zang, Kejun Deng, Jianping Zhou, Yong Zhang   +8 more
doaj   +1 more source

Genomic Characterization of Variable Surface Antigens Reveals a Telomere Position Effect as a Prerequisite for RNA Interference-Mediated Silencing in Paramecium tetraurelia

mBio, 2014
Antigenic or phenotypic variation is a widespread phenomenon of expression of variable surface protein coats on eukaryotic microbes. To clarify the mechanism behind mutually exclusive gene expression, we characterized the genetic properties of the ...
Damir Baranasic, Timo Oppermann, Miriam Cheaib, John Cullum, Helmut Schmidt, Martin Simon   +5 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Genome-wide transcriptome analysis reveals small RNA profiles involved in early stages of stolon-to-tuber transitions in potato under photoperiodic conditions

BMC Plant Biology, 2018
Background Small RNAs (sRNAs), especially miRNAs, act as crucial regulators of plant growth and development. Two other sRNA groups, trans-acting short-interfering RNAs (tasiRNAs) or phased siRNAs (phasiRNAs), are also emerging as potential regulators of ...
Kirtikumar Ramesh Kondhare, Nilam Namdeo Malankar, Ravi Suresh Devani, Anjan Kumar Banerjee   +3 more
doaj   +1 more source

Development of plants resistant to tomato geminiviruses using artificial trans-acting small interfering RNA.

Molecular plant pathology, 2015
RNA interference (RNAi), a conserved RNA-mediated gene regulatory mechanism in eukaryotes, plays an important role in plant growth and development, and as an antiviral defence system in plants. As a counter-strategy, plant viruses encode RNAi suppressors
Archana Singh, J. Taneja, I. Dasgupta, S. Mukherjee   +3 more
semanticscholar   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source