Mycobacterial and HIV infections up-regulated human zinc finger protein 134, a novel positive regulator of HIV-1 LTR activity and viral propagation. [PDF]
PLoS ONE, 2014 BACKGROUND: Concurrent occurrence of HIV and Tuberculosis (TB) infections influence the cellular environment of the host for synergistic existence.
Ronald Benjamin +5 more
doaj +1 more source
A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs. [PDF]
, 2017 mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown
Ding, Junjun +14 more
core +1 more source
STAT3‐mediated MLST8 gene expression regulates cap‐dependent translation in cancer cells
Molecular Oncology, 2020 Signal transducer and activator of transcription 3 (STAT3) regulates cell growth, cell survival, angiogenesis, metastasis of cancer cells, and cancer immune evasion by regulating gene expression as a transcription factor.
Hyunji Lee +4 more
doaj +1 more source
Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. [PDF]
, 2007 Despite several investigations, the transcriptional mechanisms that regulate the expression of both type I collagen genes (COL1A1 and COL1A2) in either physiological or pathological situations, such as scleroderma, are not completely known.
Beauchef, Gallic +11 more
core +2 more sources
MIGS as a Simple and Efficient Method for Gene Silencing in Rice
Frontiers in Plant Science, 2018 MiRNA-induced gene silencing (MIGS) technology is a special kind of RNA interference technology that uses miR173 to mediate the production of trans-acting siRNA (ta-siRNA) to achieve target gene silencing.
Xuelian Zheng +8 more
doaj +1 more source
NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib [PDF]
, 2017 NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and ...
Bown, James L. +5 more
core +6 more sources
H3 histamine receptor-mediated activation of protein kinase calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo [PDF]
, 2009 Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The D-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth.
A. Vetuschi +13 more
core +1 more source
mBio, 2014 Antigenic or phenotypic variation is a widespread phenomenon of expression of variable surface protein coats on eukaryotic microbes. To clarify the mechanism behind mutually exclusive gene expression, we characterized the genetic properties of the ...
Damir Baranasic +5 more
doaj +1 more source
Systematic discovery of structural elements governing stability of mammalian messenger RNAs. [PDF]
, 2012 Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour.
Cristea, Ileana M +7 more
core +2 more sources
Sequencing of RDR6-dependent double-stranded RNAs reveals novel features of plant siRNA biogenesis [PDF]
, 2017 Biogenesis of trans-acting siRNAs (tasiRNAs) is initiated by miRNA-directed cleavage of TAS gene transcripts and requires RNA-dependent RNA polymerase 6 (RDR6) and Dicer-like 4 (DCL4).
Aregger, Michael +5 more
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