Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
Impact of C-Terminal PKC Phosphorylation on TRPC6 Current Kinetics. [PDF]
Int J Mol SciKeck M +6 more
europepmc +1 more source
Cloning and characterization of a gene whose product is a trans-activator of anthrax toxin synthesis
, 1993 Ikuo Uchida +4 more
openalex +2 more sources
Global and local perturbation of the tomato microRNA pathway by atrans-activatedDICER-LIKE 1mutant [PDF]
, 2013 Michael Kravchik +6 more
openalex +1 more source
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder
Advanced Science, EarlyView.NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai +13 more
wiley +1 more source
A multifunctional switch for label-free CRISPR/Cas12a sensor with self-driven amplification. [PDF]
Synth Syst BiotechnolLi P +6 more
europepmc +1 more source
The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain. [PDF]
, 1991 Shani Stern, Winship Herr
openalex +1 more source
Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants
Advanced Science, EarlyView.In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao +12 more
wiley +1 more source
Advancements and Applications of Split Technology in CRISPR/Cas12a: Transforming Molecular Diagnostics and Biosensing. [PDF]
Biosensors (Basel)Jayakumar S +5 more
europepmc +1 more source