Results 251 to 260 of about 56,323 (331)

Natural Compounds Targeting <i>SIRT1</i> and Beyond: Promising Nutraceutical Strategies Against Atherosclerosis. [PDF]

Nutrients
Domi E, Hoxha M.
europepmc   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Combinatorial protein engineering identifies potent CRISPR activators with reduced toxicity. [PDF]

Nat Commun
Giddins M, Kratz AF, De Los Santos MB, Forget A, Tiwari R, Jang G, Blazejewski T, Qin C, Huang Y, Lao YH, Falconer T, Leong KW, Krogan N, Staller M, Wang H, Wei L, Chavez A.   +16 more
europepmc   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

High-valent sulfur fluorides as reactivity switches for PFAS-free benzene-azepine skeletal editing. [PDF]

Chem Sci
Nagababu C, Muramatsu T, Bacho MZ, Wu S, Ochiai S, Escorihuela J, Shibata N.   +6 more
europepmc   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

MnO₂ Nanosponge-Accelerated Cas12a Trans-Cleavage: Breaking the Kinetic Barrier for In Vivo RNA Imaging. [PDF]

Adv Sci (Weinh)
Liu WJ, Wang LY, Ma F, Zhang CY.
europepmc   +1 more source

La trans-activation du virus LAV est traductionnelle [PDF]

médecine/sciences, 1986
openaire   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

'Splice-at-will' Cas12a crRNA engineering enabled direct quantification of ultrashort RNAs. [PDF]

Nucleic Acids Res
Fei X, Lei C, Ren W, Liu C.
europepmc   +1 more source