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Molecular and Cellular Endocrinology, 2019 In this study, we determined whether estragole and its isomer trans-anethole interfered with feto-placental steroidogenesis in a human co-culture model composed of fetal-like adrenocortical (H295R) and placental trophoblast-like (BeWo) cells.
Thomas Sanderson, Cathy Vaillancourt
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Chronic toxicity/carcinogenicity study of trans-anethole in rats
Food and Chemical Toxicology, 1989A chronic feeding study was carried out in rats with trans-anethole. The test substance was administered in the diet to groups (n = 26-78) of 312 male and 312 female Sprague-Dawley rats at concentrations of 0, 0.25, 0.5 and 1% for 117-121 wk. The average intakes of trans-anethole varied from 105-550 mg/kg body weight/day.
R, Truhaut +5 more
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Retention of trans-anethole by gelatine and starch matrices
Food Chemistry, 2010The retention of trans-anethole by gelatine gels (2.5, 5, 10 and 20 wt.%) and starch solutions (10 and 20 wt.%) was investigated by Static Headspace Gas Chromatography. Prior to analysis the samples were left to equilibrate for 24 h at 5 and 37 °C, respectively.
Triada Zafeiropoulou +4 more
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Genotoxicity of trans-anethole in vitro
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1995Trans-anethole genotoxicity has been evaluated previously both in vitro and in vivo. To ascertain the reproducibility and relevance of previously conducted gene mutation studies, the Salmonella/microsome test and the L5178Y mouse lymphoma TK+/- assay were repeated according to the protocols that previously produced positive results.
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Anti-genotoxicity of trans-anethole and eugenol in mice
Food and Chemical Toxicology, 2001The naturally occurring flavouring agents trans-anethole and eugenol were evaluated for antigenotoxic effects in mice. The test doses of trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg weight) were administered by gavage 2 and 20 h before the genotoxins were injected intraperitoneally.
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Photochemical & Photobiological Sciences, 2007
The photochemical behaviour of spontaneously formed microemulsions obtained upon dilution of ethanolic solutions of trans-anethole (E-1-(4-methoxyphenyl)propene, t-A) with water is compared to that of homogeneous ethanolic t-A solutions. Significant differences in reactivity reflect the confined nature of the aggregated t-A which leads to reduced ...
David, Carteau +3 more
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The photochemical behaviour of spontaneously formed microemulsions obtained upon dilution of ethanolic solutions of trans-anethole (E-1-(4-methoxyphenyl)propene, t-A) with water is compared to that of homogeneous ethanolic t-A solutions. Significant differences in reactivity reflect the confined nature of the aggregated t-A which leads to reduced ...
David, Carteau +3 more
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Pathways of metabolism of [1'-14C]-trans-anethole in the rat and mouse.
Drug Metabolism and Disposition, 1996This study describes the metabolic fate of trans-4'-methoxyprop-[1-14C]enylbenzene, the natural flavor compound trans-anethole, in rats and mice given single doses of 250 mg/kg body weight. In both rats and mice, an essentially quantitative (> 95% of dose) recovery of 14C was obtained with the majority in the 0-24 hr urine.
S V, Bounds, J, Caldwell
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The FEMA GRAS Assessment of trans-Anethole Used as a Flavouring Substance
Food and Chemical Toxicology, 1999This publication is the fourth in a series of safety evaluations performed by the Expert Panel of the Flavour and Extract Manufacturers' Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavouring substances under conditions of intended use.
P Newberne +11 more
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Free Radical Terpolymerization of Trans‐Anethole, Maleic Anhydride and N‐Ethylmaleimide
Journal of Macromolecular Science, Part A, 2005Trans‐anethole (ANE) and maleic anhydride (MSA) do not homopolymerize in tetrahydrofuran and in chloroform with α,α′‐azoisobutyronitrile (AIBN) as initiator. In comparison, N‐ethylmaleimide (NEMI) is homopolymerized very slowly. From these monomers, three binary systems have been studied and their copolymerization ratios were determined at 60°C: ANE ...
Dietrich Braun, Fengchao Hu
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Retention of trans-anethole by single and double layered films based on gelatine
Food Hydrocolloids, 2015The present work investigated the retention of trans-anethole by single and double layered films based on gelatine. In the case of double layered films, gelatine was the base component whereas gellan was the upper layer. The gelatine layer was always carrying the aroma compound. Films were formed under varying drying conditions.
Vasiliki Evageliou +4 more
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