Results 81 to 90 of about 736,450 (179)

(E)-1-(5-Chlorothiophen-2-yl)-3-(p-tolyl)prop-2-en-1-one

IUCrData, 2017
In the title compound, C14H11ClOS, the trans conformation of the C=C double bond in the central enone group is confirmed by the C—C=C—C torsion angle of 178.3 (4)°.
Karthik Kumara, S. Naveen, M. G. Prabhudeva, K. Ajay Kumar, N. K. Lokanath, Ismail Warad   +5 more
doaj   +1 more source

Presentation_1_Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice.pdf

, 2018
Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain and reduction in the life quality of patients.
Sergio M. Borghi (3095643), Thacyana T. Carvalho (2145823), Felipe A. Pinho-Ribeiro (714810), Larissa Staurengo-Ferrari, Fernando Q. Cunha, Rubia Casagrande (714812), Waldiceu A. Verri, Jose C. Alves-Filho, Larissa Staurengo-Ferrari (2145817), Sergio M. Borghi, Rubia Casagrande, Kenji W. Ruiz-Miyazawa, Kenji W. Ruiz-Miyazawa (714809), Thiago M. Cunha, Stephanie Badaro-Garcia, Stephanie Badaro-Garcia (5810015), Victor Fattori, Victor Fattori (1989253), Tiago H. Zaninelli (5810012), Thiago M. Cunha (276874), Jose C. Alves-Filho (530003), Waldiceu A. Verri (1989247), Fernando Q. Cunha (276880), Tiago H. Zaninelli, Thacyana T. Carvalho, Felipe A. Pinho-Ribeiro   +25 more
core   +1 more source

New “Green” Approaches to the Synthesis of Pyrazole Derivatives

Molecules, 2007
A novel approach to the synthesis of pyrazole derivatives from tosylhydrazones of α,β-unsaturated carbonyl compounds possessing a β-hydrogen is proposed, exploiting microwave (MW) activation coupled with solvent free reaction conditions.
Carla Villa, Sara Baldassari, Romano Grandi, Paolo Veronesi, Roberto Rosa, Antonino Rizzuti, Cristina Leonelli, Anna Corradi   +7 more
doaj   +1 more source

Ruthenium Complexes with PYA Pincer Ligands for Catalytic Transfer Hydrogenation of Challenging Substrates

CHIMIA, 2019
Here we highlight the potential of a series of ruthenium complexes with tridentate N,N,N pincer-type ligands featuring two pyridylidene amide (PYA) moieties in the ligand skeleton.
Philipp Melle, Martin Albrecht
doaj   +1 more source

Protective Effects of Trans-Chalcone on Myocardial Ischemia and Reperfusion Challenge through Targeting Phosphoinositide 3-kinase/Akt-inflammosome Interaction

Journal of Physiological Investigation
Ischemia-reperfusion (IR) injury remains a pivotal contributor to myocardial damage following acute coronary events and revascularization procedures. Phosphoinositide 3-kinase (PI3K), a key mediator of cell survival signaling, plays a central role in ...
Jing Wang, Shaik Althaf Hussain, Narendra Maddu, Haijun Li   +3 more
doaj   +1 more source

Additional file 1: of Trans-chalcone activity against Trichophyton rubrum relies on an interplay between signaling pathways related to cell wall integrity and fatty acid metabolism

, 2019
Table S1. Genes modulated by Trichophyton rubrum during growth on protein sources, and after trans-chalcone exposure.
Pablo Sanches (6727436), Iran Malavazi (81124), Mozart Marins (5641772), Geraldo Passos (6727442), Claudia Macedo (5650693), Matheus Franco (6727424), Bruna Cantelli (6727433), Rene Beleboni (6727439), Marina Rocha (6727427), Igor Moreli (6727430), Ana Fachin (6727445), Tamires Bitencourt (6727421)   +11 more
core   +1 more source

The effect of the fused-ring substituent on anthracene chalcones: crystal structural and DFT studies of 1-(anthracen-9-yl)-3-(naphthalen-2-yl)prop-2-en-1-one and 1-(anthracen-9-yl)-3-(pyren-1-yl)prop-2-en-1-one

Acta Crystallographica Section E: Crystallographic Communications, 2018
The title chalcone compounds, C27H18O (I) and C33H20O (II), were synthesized using a Claisen–Schmidt condensation. Both compounds display an s-trans configuration of the enone moiety.
Dian Alwani Zainuri, Ibrahim Abdul Razak, Suhana Arshad   +2 more
doaj   +1 more source

(E)-1-(4-Aminophenyl)-3-(naphthalen-2-yl)prop-2-en-1-one

Acta Crystallographica Section E, 2011
The molecule of the title chalcone derivative, C19H15NO, exists in a trans configuration with respect to the C=C double bond. The molecule is slightly twisted with a dihedral angle of 6.12 (12)° between the benzene ring and the ...
Thawanrat Kobkeatthawin, Suchada Chantrapromma, Nisakorn Saewan, Hoong-Kun Fun   +3 more
doaj   +1 more source

Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest

Biomedicine & Pharmacotherapy, 2017
Chalcones are precursors of flavonoids that exhibit structural heterogeneity and potential antitumor activity. The objective of this study was to characterize the cytotoxicity of trans-chalcone and licochalcone A (LicoA1) against a breast cancer cell line (MCF-7) and normal murine fibroblasts (3T3).
Luis Felipe Buso, Bortolotto, Flávia Regina, Barbosa, Gabriel, Silva, Tamires Aparecida, Bitencourt, Rene Oliveira, Beleboni, Seung Joon, Baek, Mozart, Marins, Ana Lúcia, Fachin   +7 more
openaire   +2 more sources

Anticancer and antimicrobial activity of methoxy amino chalcone derivatives [PDF]

, 2015
A series of methoxy amino chalcone derivatives have been synthesized and evaluated for their anticancer activity against breast cancer cells line T47D and their antimicrobial activity against Escherichia coli ATCC 25923, Staphylococcus aureus ATCC 25922,
Mustofa, .-, Ni’matuzahroh, .-, Jumina, .-, Ni Nyoman Tri Puspaningsih, .-, Hery Suwito, .-   +4 more
core