Results 81 to 90 of about 873,934 (176)

Acarbose versus trans-chalcone: comparing the effect of two glycosidase inhibitors on obese mice

, 2015
Objective Acarbose and trans-chalcone are glucosidase inhibitors whose beneficial effects have been demonstrated in diabetes. The present study aimed at investigating their potential effects in obesity.Materials and methods NMRI male mice (n = 48) were ...
Parichehreh Yaghmaei (6045917), Masoud Kimiagar (6153830), Azadeh Ebrahim-Habibi (6045923), Fatemeh Jalalvand (6153827), Mahsa M. Amoli (5581760)   +4 more
core   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

New “Green” Approaches to the Synthesis of Pyrazole Derivatives

Molecules, 2007
A novel approach to the synthesis of pyrazole derivatives from tosylhydrazones of α,β-unsaturated carbonyl compounds possessing a β-hydrogen is proposed, exploiting microwave (MW) activation coupled with solvent free reaction conditions.
Carla Villa, Sara Baldassari, Romano Grandi, Paolo Veronesi, Roberto Rosa, Antonino Rizzuti, Cristina Leonelli, Anna Corradi   +7 more
doaj   +1 more source

Presentation_1_Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice.pdf

, 2018
Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain and reduction in the life quality of patients.
Sergio M. Borghi (3095643), Thacyana T. Carvalho (2145823), Felipe A. Pinho-Ribeiro (714810), Larissa Staurengo-Ferrari, Fernando Q. Cunha, Rubia Casagrande (714812), Waldiceu A. Verri, Jose C. Alves-Filho, Larissa Staurengo-Ferrari (2145817), Sergio M. Borghi, Rubia Casagrande, Kenji W. Ruiz-Miyazawa, Kenji W. Ruiz-Miyazawa (714809), Thiago M. Cunha, Stephanie Badaro-Garcia, Stephanie Badaro-Garcia (5810015), Victor Fattori, Victor Fattori (1989253), Tiago H. Zaninelli (5810012), Thiago M. Cunha (276874), Jose C. Alves-Filho (530003), Waldiceu A. Verri (1989247), Fernando Q. Cunha (276880), Tiago H. Zaninelli, Thacyana T. Carvalho, Felipe A. Pinho-Ribeiro   +25 more
core   +1 more source

Protective Effects of Trans-Chalcone on Myocardial Ischemia and Reperfusion Challenge through Targeting Phosphoinositide 3-kinase/Akt-inflammosome Interaction

Journal of Physiological Investigation
Ischemia-reperfusion (IR) injury remains a pivotal contributor to myocardial damage following acute coronary events and revascularization procedures. Phosphoinositide 3-kinase (PI3K), a key mediator of cell survival signaling, plays a central role in ...
Jing Wang, Shaik Althaf Hussain, Narendra Maddu, Haijun Li   +3 more
doaj   +1 more source

Ruthenium Complexes with PYA Pincer Ligands for Catalytic Transfer Hydrogenation of Challenging Substrates

CHIMIA, 2019
Here we highlight the potential of a series of ruthenium complexes with tridentate N,N,N pincer-type ligands featuring two pyridylidene amide (PYA) moieties in the ligand skeleton.
Philipp Melle, Martin Albrecht
doaj   +1 more source

The Effect of Trans-Chalcone on Amylase Activity, Blood Glucose and Lipid Levels in Diabetic and Non Diabetic Rats

Armaghane Danesh Bimonthly Journal, 2011
Introduction & Objective: Alpha amylase is the most important decomposing enzyme in starch. Digestion and absorption of starch in the intestine can be prevented and also the blood sugar levels can be controlled by restrain and control of alpha amylase ...
M Najafian, A Ebrahim-Habibi, P Yaghmaei, K Parivar, B Larijani   +4 more
doaj  

Synthesis, Characterization, Antioxidant Activity and Conformational Study of 4-Hydroxychalcone

Orbital: The Electronic Journal of Chemistry, 2021
The objective of this work was to develop a synthesis, characterization, and conformational study of 4-hydroxychalcone. The chalcone was obtained using Claisen-Schmidt reaction. The product was characterized by IR and NMR spectroscopy.
André Luis Kerek, Thiago de Castro Rozada, Barbara Celânia Fiorin   +2 more
doaj  

Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest

Biomedicine & Pharmacotherapy, 2017
Chalcones are precursors of flavonoids that exhibit structural heterogeneity and potential antitumor activity. The objective of this study was to characterize the cytotoxicity of trans-chalcone and licochalcone A (LicoA1) against a breast cancer cell line (MCF-7) and normal murine fibroblasts (3T3).
Luis Felipe Buso, Bortolotto, Flávia Regina, Barbosa, Gabriel, Silva, Tamires Aparecida, Bitencourt, Rene Oliveira, Beleboni, Seung Joon, Baek, Mozart, Marins, Ana Lúcia, Fachin   +7 more
openaire   +2 more sources

Anticancer and antimicrobial activity of methoxy amino chalcone derivatives [PDF]

, 2015
A series of methoxy amino chalcone derivatives have been synthesized and evaluated for their anticancer activity against breast cancer cells line T47D and their antimicrobial activity against Escherichia coli ATCC 25923, Staphylococcus aureus ATCC 25922,
Mustofa, .-, Ni’matuzahroh, .-, Jumina, .-, Ni Nyoman Tri Puspaningsih, .-, Hery Suwito, .-   +4 more
core   +2 more sources