Results 71 to 80 of about 20,166,631 (253)

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Final report

, 2010
Title from cover.; Earlier ed. issued as: Preliminary report / State of Connecticut, Electric Vehicle Infrastructure Council ; by Kevin M. DelGobbo, Joan McDonald.
Connecticut. Electric Vehicle Infrastructure Council.
core   +1 more source

Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

Translational Neurodegeneration, 2019
Background We recently demonstrated an endolysosomal accumulation of the β-secretase-derived APP C-terminal fragment (CTF) C99 in brains of Alzheimer disease (AD) mouse models.
Inger Lauritzen, Anaïs Bécot, Alexandre Bourgeois, Raphaëlle Pardossi-Piquard, Maria-Grazia Biferi, Martine Barkats, Fréderic Checler   +6 more
doaj   +1 more source

Intelligent Polymer Electrolytes for Next‐Generation Zinc‐Based Energy Storage Devices

Advanced Science, EarlyView.
Intelligent polymer electrolytes are organized into a three‐level hierarchy that advances zinc‐based energy storage from passive ion conduction toward active, adaptive, and intelligent operation. Molecular regulation of Zn+ coordination, water activity, desolvation, ion flux, and interfaces underpins adaptive self‐healing, anti‐freezing, adhesion, and ...
Sanath Kumar, Jhansirani Kesavan, Muhammad Asim, Atul Verma, Yen‐Pei Fu   +4 more
wiley   +1 more source

A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis

Advanced Science, EarlyView.
Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee, Jaeyoung Yoo, Young A. Kim, Zhuodu Wei, Yunseo Lee, Woo‐Jeong Shon, Je Kyung Seong, Seunghee Lee   +7 more
wiley   +1 more source

RBFNN-Based Adaptive Fixed-Time Sliding Mode Tracking Control for Coaxial Hybrid Aerial–Underwater Vehicles Under Multivariant Ocean Disturbances

Drones
In this study, the design of an adaptive neural network-based fixed-time control system for a novel coaxial trans-domain hybrid aerial–underwater vehicle (HAUV) is investigated.
Mingqing Lu, Wei Yang, Zhenyu Xiong, Fei Liao, Shichong Wu, Yumin Su, Wenhua Wu   +6 more
doaj   +1 more source

Serialising Gender, Breeding Race: Biopolitics in Game of Thrones

, 2015
Paper presented at Trans/Forming Feminisms: Media, Technology, Identity, November 23-25, University of Otago, Dunedin, New ...
Laurie, T
core  

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

Interbody Wire for Reconfigurable Robots: Bridging Integrated Morphological Reconfiguration and Distributed Wire‐Mediated Cooperation

Advanced Intelligent Systems, EarlyView.
TwinX shows how a single interbody wire connecting two robots can support both integrated morphological reconfiguration and distributed wire‐mediated cooperation. When the robots dock, they reconfigure into different forms for locomotion and manipulation.
Shintaro Inoue, Kento Kawaharazuka, Keita Yoneda, Sota Yuzaki, Temma Suzuki, Kei Okada   +5 more
wiley   +1 more source