Results 41 to 50 of about 2,895,452 (235)

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Supplementation of retinoic acid alone in MSC culture medium induced germ cell-like cell differentiation

open access: yesJournal of Animal Reproduction and Biotechnology, 2023
Background: Germ cells undergo towards male or female pathways to produce spermatozoa or oocyte respectively which is essential for sexual reproduction.
Kuldeep Kumar   +6 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

The grapevine ABC transporter B family member 15 is a trans-resveratrol transporter out of grapevine cells

open access: yesFrontiers in Plant Science
Stilbenes, particularly trans-resveratrol, play a highly relevant defense role in grapevines as phytoalexin is induced in response to stress. Metabolism and transport of stilbenes can be conveniently investigated in grapevine cell culture since large ...
Ascensión Martínez-Márquez   +9 more
doaj   +1 more source

Geroprotective activity of trans-cinnamic acid isolated from the Baikal skullcap (Scutellaria baicalensis)

open access: yesТехника и технология пищевых производств, 2022
Trans-cinnamic acid is a phenolic compound with a wide range of bioactive properties, including antioxidant and antibacterial effects. It also has high potential in the food and cosmetic industries. We aimed to isolate trans-cinnamic acid from the Baikal
Anastasiya M. Fedorova   +5 more
doaj   +1 more source

Trans Ecologies Symposium [PDF]

open access: yes, 2023
‘The Shelled Gastropod: Trans-Corporeality In Necro-Ecologies’ was presented as part of the Trans Ecologies Symposium, Department of Geography at Durham University. Abstract: This paper contributes to contemporary dialogues on the permeability of bodies,
Sharples, V.
core  

Trans Time: Safety, Privacy, and Content Warnings on a Transgender-Specific Social Media Site [PDF]

open access: yes, 2020
Trans people often use social media to connect with others, find and share resources, and post transition-related content. However, because most social media platforms are not built with trans people in mind and because online networks include people who
Haimson, Oliver L.   +11 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

The Increase of Triterpene Saponin Production Induced by Trans-Anethole in Hairy Root Cultures of Panax quinquefolium

open access: yesMolecules, 2018
In vitro cultivation is an effective way to increase pharmaceutical production. To increase ginsenoside production in hairy root cultures of American ginseng, the present study uses trans-anethole as an elicitor.
Ewa Kochan   +6 more
doaj   +1 more source

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