Results 151 to 160 of about 3,641,959 (223)

A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration. [PDF]

EMBO Rep
Dehio P, Michard C, Yam-Puc JC, Martí I Líndez AA, Jandke A, Unterstab G, Fabre L, Sauteur L, Artinger M, Legler DF, Sixt M, Schaefer T, Wymann MP, Okkenhaug K, Soldati T, Mehling M, Hess C.   +16 more
europepmc   +1 more source

Distinct Skin Penetration and Immune Responses to Ionic and Nanoparticulate Cobalt in Allergic Contact Dermatitis

Allergy, EarlyView.
Cobalt chloride (CoCl2) and cobalt nanoparticles (CoNPs) induce a shared, severity‐dependent inflammatory response in cobalt‐sensitized skin characterized by activation of interferon signaling, inflammatory pathways (TNF/NF‐κβ, IL6‐STAT3), apoptosis/UPR, cell cycle programs, and glycolysis.
Paulina Werner, Martin Schaier, Gabriel Braun, Anneli Julander, Klara Midander, Marlene Isaksson, Gunda Koellensperger, Lukas Wisgrill, Nanna Fyhrquist   +8 more
wiley   +1 more source

Inhibition of endolysosomal two-pore channel 2 (TPC2) induces osteoblast differentiation and matrix mineralization while targeting autophagy. [PDF]

J Endocrinol Invest
Montaseri A, Rossi M, Battafarano G, Riccioli A, Palombi F, Giampietri C, Liguoro D, Mancini R, Meucci M, Palmisano B, Riminucci M, Keller M, Bracher F, Grimm C, Umehara K, De-Eknamkul W, Filippini A, Del Fattore A.   +17 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

In vitro toxicity of piperazine derivatives involves mitochondrial dysfunction and microtubule-related changes in neuronal cell models. [PDF]

BMC Pharmacol Toxicol
Rönnberg D, Jacobsson SOP.
europepmc   +1 more source

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

Impact of storage conditions on the stability and biological efficacy of trans-arachidin-1 and trans-arachidin-3. [PDF]

PLoS One
Khongrungjarat P, Tothong C, Pankaew C, Phimsen S, Khamto N, Kijchalao N, Wongkham W, Wongkham P, Chuaymaung W, Thonnondang A, Limmongkon A.   +10 more
europepmc   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Functional relationships linking C99/APP-βCTF dimerization, proteostasis disruption, and organelle dysfunction. [PDF]

Cell Commun Signal
Badot C, Bini A, Duplan E, Checler F, Lauritzen I.   +4 more
europepmc   +1 more source