A New Trans-Tympanic Microphone Approach for Fully Implantable Hearing Devices [PDF]
Sensors, 2015 Fully implantable hearing devices (FIHDs) have been developed as a new technology to overcome the disadvantages of conventional acoustic hearing aids.
Seong Tak Woo +7 more
doaj +4 more sources
Peptide-Mediated Transport Across the Intact Tympanic Membrane Is Intracellular, with the Rate Determined by the Middle Ear Mucosal Epithelium [PDF]
BiomoleculesThe tympanic membrane forms an impenetrable barrier between the ear canal and the air-filled middle ear, protecting it from fluid, pathogens, and foreign material entry.
Arwa Kurabi +4 more
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QbD Design, Formulation, Optimization and Evaluation of Trans-Tympanic Reverse Gelatination Gel of Norfloxacin: Investigating Gene-Gene Interactions to Enhance Therapeutic Efficacy [PDF]
Gels, 2023 Traditional otic drug delivery methods lack controlled release capabilities, making reverse gelatination gels a promising alternative. Reverse gelatination gels are colloidal systems that transition from a sol to a gel phase at the target site, providing
Amit Budhori +11 more
doaj +2 more sources
A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer [PDF]
Journal of Otolaryngology - Head and Neck Surgery, 2019 Background Cisplatin-induced hearing loss is frequent and severe. Antioxidants such as sodium thiosulfate (STS) can neutralize the effects of cisplatin.
Viannique Rolland +7 more
doaj +2 more sources
Tympanic membrane perforation treated with Adelmidrol and Trans-traumatic acid: Two case reports
Otolaryngology Case Reports, 2021 Tympanic membrane perforation is a very common clinical condition encountered in otological practice; it can result from a large variety of causes such as trauma or infections.
Patrizia Scavone
doaj +3 more sources
Dynamic Nanopeptide Assemblies for Trans-Tympanic Drug Delivery [PDF]
International Journal of NanomedicineEvan A Patel,1 Swapnil V Shah,1 Trevor A Poulson,1 H Christopher Fry,2 Ashok A Jagasia1 1Department of Otolaryngology, Head and Neck Surgery, Rush University Medical Center, Chicago, IL, 60612, USA; 2Center for Nanoscale Material, Argonne National ...
Patel EA +4 more
doaj +2 more sources
A Novel Drug-Loaded Porous Parylene Electrode for Targeted Anti-Inflammatory Therapy and Hearing Preservation in Cochlear Implantation. [PDF]
Adv Healthc MaterA porous parylene‐coated electrode loaded with dexamethasone was developed to reduce inflammation after cochlear implantation. In guinea pigs, the device provided sustained drug release, maintained biocompatibility, improved auditory brainstem response thresholds, and reduced inflammatory cell infiltration and TNF‐α expression.
Chang CC +11 more
europepmc +2 more sources
A Case of Acquired Pars Flaccida Cholesteatoma Extending to the Supralabyrinthine Petrous Apex With Preservation of the Otic Capsule. [PDF]
Case Rep OtolaryngolBackground Supralabyrinthine petrous bone cholesteatoma is a rare subtype in which hearing preservation may be achievable depending on the anatomical extent and surgical approach. Appropriate selection of surgical strategy is essential. Case Presentation A 31‐year‐old man presented with a 2‐year history of persistent left otorrhea.
Sugimoto H +3 more
europepmc +2 more sources
Mastoid Surgery Does Not Normalize Tympanometric Middle Ear Pressure in Children With Cholesteatoma. [PDF]
LaryngoscopeConflicting mechanism‐based hypotheses have been used to promote selection of different approaches to management of the mastoid in order to optimize middle ear pressure homeostasis after removal of cholesteatoma. For example: (a) conservation of mastoid mucosa and opening of ventilation pathways endoscopically to normalize function, (b) removal of ...
James AL.
europepmc +2 more sources
Unilateral Nasopharyngeal Endoscopic Resection Type III: Technical Notes. [PDF]
LaryngoscopeThe present video case report details technical notes of Nasopharyngeal Endoscopic Resection (NER) Type III, performed for a mucosal melanoma in a 71‐year‐old patient. Key surgical steps—such as achieving optimal exposure, employing Doppler‐guided internal carotid artery localization, and applying vascularized flap coverage—are outlined, demonstrating ...
Conti C +7 more
europepmc +2 more sources