Formulations for trans-tympanic antibiotic delivery [PDF]
Biomaterials, 2013 We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs -
Daniel Kohane +2 more
exaly +8 more sources
Trans-tympanic Cartilage Chip Insertion for Intractable Patulous Eustachian Tube [PDF]
Journal of Audiology and Otology, 2018 Patulous Eustachian tube (PET) causes troublesome autophony. We treated PET using tragal cartilage chip insertion to fill in the concavity within the tubal valve and evaluated the feasibility of this method.This study used a prospective design. Eleven patients with PET disorder were included.
Seung Ho Shin +2 more
exaly +6 more sources
Novel hybrid tri-polymer hyalurosomes: unlocking next-generation trans-tympanic therapeutics through multi-Scale evaluations [PDF]
International Journal of Pharmaceutics: XAcute otitis media (AOM) remains one of the most common middle ear infections, particularly in children, necessitating advanced non-invasive therapeutic strategies. This study introduces Novel Hybrid Tri-Polymer Hyalurosomes, an innovative vesicular system designed to enhance trans-tympanic delivery of ciprofloxacin (CFX).
Sadek Ahmed, Heba Attia
exaly +4 more sources
Engineered Inner Ear Drug Delivery Systems for Hearing Loss Treatment [PDF]
ResearchHearing loss is becoming a common disease worldwide, affecting individuals across all age groups, from infants to older adults. However, the unique anatomical barriers of the inner ear limit the effectiveness of conventional systemic therapies ...
Zhiyan Xuan +5 more
doaj +2 more sources
Peptides rapidly transport antibiotic across the intact tympanic membrane to treat a middle ear infection [PDF]
Drug DeliveryThe tympanic membrane (TM) forms an impenetrable barrier to medical therapies for middle ear (ME) diseases like otitis media. By screening a phage-displayed peptide library, we have previously discovered rare peptides that mediate the active transport of
Arwa Kurabi, Emily Sereno, Allen F. Ryan
doaj +2 more sources
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity. [PDF]
J Vis Exp, 2018 The systemic administration of protective agents to treat drug-induced ototoxicity is limited by the possibility that these protective agents could interfere with the chemotherapeutic efficacy of the primary drugs. This is especially true for the drug cisplatin, whose anticancer actions are attenuated by antioxidants which provide adequate protection ...
Sheehan K +4 more
europepmc +4 more sources
A study of tympanic membrane displacement [PDF]
, 1980 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Presented in this thesis is a study relating to the measurement of tympanic membrane displacement.
Marchbanks, Robert
core +7 more sources
Tympanic Pre-Operative Electrically Evoked Auditory Late Response (TympEALR) as an Alternative to Trans-Tympanic Tests Using Anesthesia in Cochlear Implant Candidacy. [PDF]
J Clin MedBackground/Objectives: Before a cochlear implant is considered, patients undergo various audiological tests to assess their suitability. One key test measures the auditory brainstem response (ABR) to acoustic stimuli.
Polterauer D, Neuling M, Simon F.
europepmc +2 more sources
Comment on: Trans-Tympanic Cartilage Chip Insertion for Intractable Patulous Eustachian Tube. [PDF]
J Audiol Otol, 2019 Boedts MJ.
europepmc +4 more sources
The Laryngoscope, 2010 Objective:This study aimed to assess the feasibility of using a 1.3 mm, semi-rigid, interventional salivary endoscope for middle-ear endoscopy, and as a trans-tympanic route for delivery of medication, in human cadaveric temporal bones.Study design:Human
M A Arriaga +5 more
core +4 more sources