Results 51 to 60 of about 871,253 (175)

Ultrasound Microbubble–Facilitated Inner Ear Delivery of Gold Nanoparticles Involves Transient Disruption of the Tight Junction Barrier in the Round Window Membrane

Frontiers in Pharmacology, 2021
The application of ultrasound microbubbles (USMBs) enhances the permeability of the round window membrane (RWM) and improves drug delivery to the inner ear.
Yi-Chun Lin, Cheng-Ping Shih, Hsin-Chien Chen, Ying-Liang Chou, Ying-Liang Chou, Huey-Kang Sytwu, Huey-Kang Sytwu, Mei-Cho Fang, Yuan-Yung Lin, Yuan-Yung Lin, Chao-Yin Kuo, Hsiao-Han Su, Chia-Lien Hung, Hang-Kang Chen, Hang-Kang Chen, Chih-Hung Wang, Chih-Hung Wang, Chih-Hung Wang, Chih-Hung Wang   +18 more
doaj   +1 more source

Endoscopic Transcanal Cartilage Myringoplasty with and Without Tympano Meatal Flap Elevation [PDF]

Al-Azhar International Medical Journal
Background: Perforation of the chronic Tympanic Membrane (TM) is a common consequence of trauma and Chronic Otitis Media(COM) in adults. Tympanoplasty is a surgical procedure that repairs perforations in the tympanic membrane and restores hearing.Aim and
doaj   +1 more source

Multisystem Mucosal Morbidity in Recessive Dystrophic Epidermolysis Bullosa Inversa

Pediatric Dermatology, EarlyView.
ABSTRACT Background/Objectives Recessive dystrophic epidermolysis bullosa inversa (RDEB‐I) is a rare subtype of dystrophic epidermolysis bullosa (EB) characterized by intertriginous cutaneous involvement and frequent mucosal disease. Although mucosal involvement is recognized in RDEB‐I, its cumulative clinical burden remains poorly defined.
Valerie R. Stichert, Nichole Halliburton, Sarah Crawford, Jennifer Phillips, Kalyani S. Marathe, Beth A. Moeves   +5 more
wiley   +1 more source

Otitis media impacts hundreds of mouse middle and inner ear genes. [PDF]

PLoS ONE, 2013
Otitis media is known to alter expression of cytokine and other genes in the mouse middle ear and inner ear. However, whole mouse genome studies of gene expression in otitis media have not previously been undertaken.
Carol J MacArthur, Fran Hausman, J Beth Kempton, Dongseok Choi, Dennis R Trune   +4 more
doaj   +1 more source

An Imaging‐Guided, Patient‐Specific Guiding Aid (RWNGuide) for Safe and Reproducible Inner Ear Drug Delivery

Advanced Materials Technologies, Volume 11, Issue 18, 18 September 2026.
A patient‐specific, imaging‐guided aid enables precise and reproducible drug delivery to the inner ear. By guiding therapeutic agents directly to the round window niche, this approach reduces variability in drug localization, improves delivery safety, and addresses a critical bottleneck in inner ear therapy, offering a scalable strategy for precision ...
Yanjing Luo, Shanshan Jiang, Yimian Luo, Adele Moatti, Farnaz Matin‐Mann   +4 more
wiley   +1 more source

Treatment of Otomycosis in Ears with Tympanic Membrane Perforation is Easier with Paper Patch [PDF]

, 2019
Objective:To assess the effectiveness of paper patch closure of tympanic membrane perforation in patients with otomycosis and tympanic membrane perforation.Methods:Fifty-six otomycosis patients with central tympanic membrane perforations were included in
Yusuf Vayısoğlu, Kemal Görür, Cengiz Özcan, Onur İsmi   +3 more
core   +1 more source

Peptides actively transported across the tympanic membrane: Functional and structural properties.

PLoS ONE, 2017
Otitis media (OM) is the most common infectious disease of children under six, causing more antibiotic prescriptions and surgical procedures than any other pediatric condition.
Arwa Kurabi, Kerry A Beasley, Lisa Chang, James McCann, Kwang Pak, Allen F Ryan   +5 more
doaj   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, Volume 13, Issue 26, 8 May 2026.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Electrical stimulation of the cochlea for treatment of chronic disabling tinnitus: an open-label trial towards the development of an implantable device

Journal of Translational Medicine, 2022
Background Chronic tinnitus affects millions of people globally and constitutes the most commonly compensated disability among military service members in the United States.
John P. Marinelli, C. Lane Anzalone, Christoph M. Prummer, Gayla L. Poling, Jeffrey P. Staab, Nicole M. Tombers, Christine M. Lohse, Matthew L. Carlson   +7 more
doaj   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, Volume 13, Issue 29, 22 May 2026.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source