Results 71 to 80 of about 871,253 (175)

The cochlear apex demystified: Implications from synchrotron radiation phase‐contrast imaging and microscopy for cochlear implantation

open access: yesJournal of Anatomy, Volume 247, Issue 6, Page 1283-1296, December 2025.
This study is the first to present the detailed cellular organization and three‐dimensional (3D) tonotopic arrangement of the human organ of Corti, spiral ganglion, and central modiolus using synchrotron radiation phase‐contrast imaging (SR‐PCI) with matched histological cross‐sections.
Hao Li   +6 more
wiley   +1 more source

Possibilities of Inner Ear Barrier Models for Otologic Drug Development

open access: yesAdvanced Therapeutics, Volume 8, Issue 11, November 2025.
This review examines innovative organ chip models that reconstruct critical inner ear barriers, addressing a fundamental challenge in otologic drug development: the limited understanding of pharmaceutical behavior across these complex barriers. By replicating these barriers, the advanced models offer promising alternatives to traditional testing ...
Yeji Ahn   +7 more
wiley   +1 more source

Anti‐Inflammatory Effects of Flavonoids in Otitis Media: A Systematic Review of Pre‐Clinical Evidence

open access: yesFood Frontiers, Volume 6, Issue 6, Page 2554-2574, November 2025.
Otitis media (OM) is a middle ear infection driven by chronic inflammation, leading to tissue damage and complications such as cholesteatoma. Flavonoids, a class of polyphenols with anti‐inflammatory properties, suppress key inflammatory mediators, reducing neutrophilic infiltration and mucosal thickening. These findings suggest flavonoids as potential
Madiha Ajaz   +3 more
wiley   +1 more source

The effect of ventilation tube insertion or trans-tympanic silicone plug insertion on a patulous Eustachian tube

open access: yesActa Oto-Laryngologica, 2016
Conclusions This study suggests that long-term ventilation tube insertion is the first-choice surgical treatment for a 'sniff-type' patulous Eustachian tube (PET). When treating a refractory PET, it is important to determine whether the patient had a habitual sniff.
Shiori, Endo   +7 more
openaire   +2 more sources

Comparative Study Between Perichondrium and Composite Cartilage/Perichondrium in Endoscopic Myringoplasty for Total and Subtotal Perforations [PDF]

open access: yesInternational Journal of Medical Arts
Background: Perforations of the tympanic membrane [TM] are frequently encountered problems, often as a result of middle ear infections, traumatic injury, or complications following surgery.
Abd El-Hamied Abd El-Hady   +3 more
doaj   +1 more source

Compact Spectral Imaging: A Review of Miniaturized and Integrated Systems

open access: yesLaser &Photonics Reviews, Volume 19, Issue 21, November 6, 2025.
This review explores the rapid shift toward compact spectral imaging systems by examining four key design paradigms: Do‐It‐Yourself (DIY) platforms, freeform optics, filter‐on‐chip integration, and multifunctional metasurfaces. The discussion highlights critical applications in medicine, agriculture, and environmental monitoring, providing comparative ...
Sani Mukhtar, Amir Arbabi, Jaime Viegas
wiley   +1 more source

The anatomic determinants of conductive hearing loss secondary to tympanic membrane perforation

open access: yesJournal of Otology, 2017
Objectives: Recent studies have introduced middle ear volume (MEV) as a novel determinant of perforation-induced conductive hearing loss (CHL) in a mechanism driven by trans-tympanic membrane pressure differences.
David J. Carpenter   +3 more
doaj   +1 more source

Comparing the Audiological Success of Bone Cement to Standard Ossiculoplasty Techniques: A Systematic Review and Meta‐analysis

open access: yesOtolaryngology–Head and Neck Surgery, Volume 173, Issue 5, Page 1054-1068, November 2025.
Abstract Objective To compare the audiological success and longevity of bone cement to standard ossiculoplasty techniques. Data Sources PubMed, Embase, Cochrane Library, Medline, and the Web of Science were systematically searched for studies from the date of inception to November 8, 2024.
Natasha Dowell   +4 more
wiley   +1 more source

Advantages of horizontal centrifugation of platelet‐rich fibrin in regenerative medicine and dentistry

open access: yesPeriodontology 2000, Volume 99, Issue 1, Page 216-267, October 2025.
Abstract The aim of this comprehensive review was to evaluate comparative studies on horizontal and fixed‐angle centrifugation methods for preparing platelet‐rich fibrin (PRF). Furthermore, additional studies utilizing horizontal PRF (H‐PRF) were systematically investigated.
Nima Farshidfar   +6 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

open access: yesAdvanced Science, Volume 12, Issue 33, September 4, 2025.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu   +7 more
wiley   +1 more source

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