Results 51 to 60 of about 1,762,571 (306)

Web 2.0. Örgütlerde Etkili Bir Şekilde Kullanılabilir mi? [PDF]

open access: yesBilgi Dünyası, 2007
There is a common conception amongst higher and middlemanagement that facilities that are “good for the Internet” can betransferred for application to the enterprise intranet.
Mustafa Sağsan(Trans.)
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Trans(Gender) Justice Teach-In: The (Literal) Debate for Trans Lives - Insight from Trans Elected Officials (2023-12-13)

open access: yes, 2023
6:00 p.m. ET / Virtual / Free; Koslowski, FinkeUniversity of Minnesota Duluth. Office of Diversity and Inclusion. (2023). Trans(Gender) Justice Teach-In: The (Literal) Debate for Trans Lives - Insight from Trans Elected Officials (2023-12-13).
University of Minnesota Duluth. Office of Diversity and Inclusion
core  

Trans Nzoia County Programme Based Budget 2025/2026 [PDF]

open access: yes
The FY 2025/2026, Trans Nzoia County presents its decisive step forward through the Annual Development Plan (ADP) and budget framework aligned with its medium-term strategic ambitions.
County Government of Trans Nzoia
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Management of Recurrent Retroperitoneal Sarcoma (RPS) in the Adult: A Consensus Approach from the Trans-Atlantic RPS Working Group

open access: yes, 2016
Retroperitoneal soft tissue sarcomas (RPS) are rare tumors. Surgery is the mainstay of curative therapy, but local recurrence is common. No recommendations concerning the best management of recurring disease have been developed so far.
Jakob, Jens   +1 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

HIGHER LINGUISTIC EDUCATION IN RUSSIA: PROBLEMS OF SINOLOGISTS TRAINING

open access: yesВысшее образование в России, 2022
The article studies organizational and pedagogical problems of sinologists training at institutions of higher education in Russia. The definition of higher sinological linguistic education is given, also the main educational programs of higher ...
Tatyana L. Guruleva, Andrey V. Makarov
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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