Results 61 to 70 of about 1,762,571 (306)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Packing timber during construction of line [picture] /
, 1917 "The rose series W.13"; Commonwealth Railways logo with map of Australia --back of photo.; P1877. Postcard photograph of the construction of the Trans-Australian Railway showing camel teams carting packing ...
Trans-Australian Railway.
core
, 2015 The subdirectory /MD includes five free MD simulation trajectories of GluK2-trans complex described in the manuscript. The subdirectory /isomerization includes five forced switching simulation trajectories from trans-gluazo to cis-gluazo.
Marcus Elstner (394014) +11 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
[Passengers on Board Trans-Texas Airways Plane]
, 1955 Photograph of a Trans-Texas Airways pilot and a family of passengers standing alongside the plane, as if about to board. The pilot holds a ticket which the father and one son look at. The mother and a younger son look on. "Trans-Texas Airways" and a logo
Douglass, Neal
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
USE OF SEWAGE SLUDGE IN SOIL COMPOSITION
Вестник Кемеровского государственного университета, 2015 Utilization of sewage sludge is the problem of many cities. But the presence of heavy metals in them is the main problem for their use as components of fertilizers and as a part of soil composition.
I. V. Grekhova +3 more
doaj
De Robi a Rubí : la “trans”-formación en “otra” en la novela Soy lo que quieras llamarme
Babel: Littératures Plurielles, 2018 Este trabajo tiene por objetivo estudiar algunos aspectos que suelen aparecer en la producción literaria latinoamericana a partir del año 1994. Nos referimos a la presencia de personajes trans (travestis, transexuales y transgéneros) que se transforman ...
Henri Billard
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source