Results 51 to 60 of about 13,202 (312)
Безопасность информационных технологий, 2012 A review of several solutions for comfortable work in systems with a large number of short transactions has been produced in the work. Several common cluster design schemes of providing data identity between the nodes have been analyzed as well as ...
V. M. Nichiporchuk, V. V. Lopatkin
doaj
AWI-BS: An adaptive weight incentive for blockchain sharding
Journal of Information and Intelligence, 2023 The sharding technique enables blockchain to process transactions in parallel by dividing blockchain nodes into small groups, each of which handles a subset of all transactions.
Zuobin Ying +4 more
doaj
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Development a Generic Transaction Processing System Based on Business Process Metadata
Jurnal Sistem Informasi, 2020 The business processes has a major role in the activities of an organization. Organizations have various types of information systems that support the business processes.
Addin Gama Bertaqwa +2 more
doaj +3 more sources
Scientific Journal of Astana IT UniversityThis study examines the impact of sharding on the scalability and efficiency of blockchain systems, specifically in the development of a complex of intelligent information and communication systems for environmental monitoring of emissions into the ...
Sapar Toxanov +4 more
doaj +1 more source
Matrix: a complex amalgam of structures and functions in tumor microenvironment
FEBS Open Bio, EarlyView.The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis +3 more
wiley +1 more source
CD9‐association with PIP2 areas is regulated by a CD9 salt bridge
FEBS Open Bio, EarlyView.The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi +2 more
wiley +1 more source
Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
FEBS Open Bio, EarlyView.PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr +5 more
wiley +1 more source
MathematicsBlockchain is widely adopted for decentralized transaction management in systems like Transactive Energy (TE). Unfortunately, conventional blockchains with sequential models and restrictive participation rules do not meet energy sector requirements. High
Fabiola Marcos Solis +3 more
doaj +1 more source