Results 51 to 60 of about 368,657 (289)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Blockchain privacy: Fundamental aspects and challenges for the future Internet data sharing

IET Blockchain
Privacy concerns the majority of individuals, governments, and organizations that share data over dissimilar networks of nodes. Every kind of participant requires awareness of the data journey that unfolds inside a blockchain network with its own ...
Nikolaos Kapsoulis, Alexandros Psychas, Antonios Litke, Theodora Varvarigou   +3 more
doaj   +1 more source

Research on Block-Chain-Based Intelligent Transaction and Collaborative Scheduling Strategies for Large Grid

IEEE Access, 2020
In view of the problems of large-grid-level centralized transactions and dispatch centers with information asymmetry and high processing costs, a completely decentralized transaction architecture and a weak centralized scheduling strategy based on block ...
Xiaolin Fu, Hong Wang, Zhijie Wang
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Human–social capital and market access factors influencing agro-processing participation by small-scale agripreneurs: The moderating effects of transaction costs

Acta Commercii, 2018
Orientation: Participating in the agriculture and agro-processing chain has the potential to enhance the competitive advantage of small-scale agricultural enterprises in South Africa.
Lesibana M.V. Thindisa, Boris Urban
doaj   +1 more source

Joint Transaction Transmission and Channel Selection in Cognitive Radio Based Blockchain Networks: A Deep Reinforcement Learning Approach

, 2018
To ensure that the data aggregation, data storage, and data processing are all performed in a decentralized but trusted manner, we propose to use the blockchain with the mining pool to support IoT services based on cognitive radio networks.
Anh, Tran The, Binh, Huynh Thi Thanh, Kim, Dong In, Liang, Ying-Chang, Luong, Nguyen Cong, Niyato, Dusit   +5 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

High Availability and Load Balancing Solution Development in High Load Distributed Systems of Electronic Payments

Безопасность информационных технологий, 2012
A review of several solutions for comfortable work in systems with a large number of short transactions has been produced in the work. Several common cluster design schemes of providing data identity between the nodes have been analyzed as well as ...
V. M. Nichiporchuk, V. V. Lopatkin
doaj