Results 111 to 120 of about 357,658 (354)
Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
Liver Dysfunction in Hypothyroid Non-Pregnant Women
Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College, 2018 Objective: To evaluate the effects of under secretion of thyroid hormones and its relation with liver markers i.e. alanine transaminase (ALT) and aspartate transaminase (AST) in non-pregnant women.
Mohammad Yousaf, Zahoor Ahmad
doaj +1 more source
The FEBS Journal, 2014 During the last decade the use of transaminases for the production of pharmaceutical and fine chemical intermediates has attracted a great deal of attention. Transaminases are versatile biocatalysts for the efficient production of amine intermediates and
C. Sayer +6 more
semanticscholar +1 more source
Halofuginone is a Molecular Glue Degrader of Integrin β4
Advanced Science, EarlyView.Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong +8 more
wiley +1 more source
Serum Transaminase in Duchenne Dystrophy
Pediatric Neurology Briefs, 2011 Researchers at Children’s Hospital Boston, MA, have shown a linear relationship between serum CPK and serum ALT and AST and a logarithmic relationship between serum enzyme levels and age for boys with Duchenne (n=46) or Becker (n=9) muscular dystrophy ...
J Gordon Millichap
doaj +1 more source
Frontiers in Oncology, 2020 Background: To examine the potential prognostic significance of pretreatment De Ritis ratio (aspartate transaminase/alanine transaminase ratio) in urological cancers, including upper tract urothelial cancer (UTUC), renal cell carcinoma (RCC), prostate ...
Shiqiang Su +4 more
doaj +1 more source
Liver transplantation before 1 year of age [PDF]
, 1987 Since 1981, 20 infants younger than 1 year of age received 26 orthotopic liver transplants. Immunosuppression was with cyclosporine and corticosteroids. Thirteen (65%) of the reciplents were discharged from the hospital.
Ascher +18 more
core +1 more source
A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes
Advanced Science, EarlyView.We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen +13 more
wiley +1 more source
PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, EarlyView.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao +14 more
wiley +1 more source
Advanced Science, EarlyView.A biocompatible hydrogel coating with tissue‐like mechanics and reversible dissolution triggered by a mild, physiologically compatible temperature drop (≈37°C → ≈25°C) was developed for the transient encapsulation of implantable devices. The physically crosslinked methylcellulose, polyethylene glycol and polyacrilic acid (MC/PEG/PAA) hydrogel ...
Francesca Persano +14 more
wiley +1 more source